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Infliximab or cyclo...
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Sjöberg, Mats,1965-Department of Medicine, Skaraborgs hospital, Lidköping, Sweden
(author)
Infliximab or cyclosporine as rescue therapy in hospitalized patients with steroid-refractory ulcerative colitis : a retrospective observational study
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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John Wiley & Sons,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-21631
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-21631URI
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https://doi.org/10.1002/ibd.21680DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170754URI
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https://lup.lub.lu.se/record/2355238URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123885524URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-74846URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Cyclosporine (CsA) or infliximab (IFX) are used as rescue therapies in steroid-refractory, severe attacks of ulcerative colitis (UC). There are no data comparing the efficacy of these two alternatives. Methods: Outcome of rescue therapy was retrospectively studied in two cohorts of patients hospitalized due to steroid-refractory moderate to severe UC: 1) a Swedish-Danish cohort (n 49) treated with a single infusion of IFX; 2) an Austrian cohort (n 43) treated with intravenous CsA. After successful rescue therapy, maintenance immunomodulator treatment was given to 27/33 (82%) of IFX patients and to 31/40 (78%) of CsA patients. Endpoints were colectomy-free survival at 3 and 12 months. Kaplan-Meier and Cox regression models were used to evaluate the association between treatment groups and colectomy. Results: At 15 days, colectomy-free survival in the IFX cohort was 36/49 (73%) versus 41/43 (95%) in the CsA cohort (P = 0.005), at 3 months 33/49 (67%) versus 40/43 (93%) (P = 0.002), and at 12 months 28/49 (57%) versus 33/43 (77%) (P = 0.034). After adjusting for potential confounding factors, Cox regression analysis yielded adjusted hazard ratios for risk of colectomy in IFX-treated patients of 11.2 (95% confidence interval [CI] 2.4-53.1, P = 0.002) at 3 months and of 3.0 (95% CI 1.1-8.2, P = 0.030) at 12 months in comparison with CsA-treated patients. There were no opportunistic infections or mortality. Conclusions: Colectomy frequencies were significantly lower after rescue therapy with CsA than with a single infusion of IFX both at 3 and 12 months' follow-up. The superiority of CsA was seen principally during the first 15 days.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Walch, AndreaDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
(author)
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Hellström, Per M.,1954-Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria,Karolinska University Hospital, Solna(Swepub:uu)perhe742
(author)
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Gustavsson, Anders,1964-Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)argn
(author)
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Järnerot, GunnarÖrebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
(author)
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Vogelsang, HaraldDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
(author)
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Hertervig, ErikLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Lund University(Swepub:lu)med-ehe
(author)
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Novacek, GottfriedDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
(author)
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Friis-Liby, IngalillDepartment of Medicine, Division of Gastroenterology, Sahlgrenska University Hospital, Gothenburg, Sweden
(author)
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Blomquist, LarsDepartment of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Stockholm, Sweden
(author)
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Angelberger, SieglindeDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
(author)
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Karlén, PerKarolinska Institutet,Södersjukhuset, Stockholm
(author)
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Granno, ChristerDepartment of Medicine, Division of Gastroenterology, Ryhov Hospital, Jönköping, Sweden
(author)
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Vilien, MogensDivision of Gastroenterology, Hilleroed Hospital, Hilleroed, Denmark
(author)
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Ström, MagnusÖstergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)magst47
(author)
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Verbaan, HansLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital, Malmö(Swepub:lu)medf-hve
(author)
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Hellström, Per M.Department of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Stockholm, Sweden
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Dejaco, ClemensDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
(author)
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Magnuson, AndersClinical epidemiology and biostatistic unit, Örebro University Hospital, Örebro, Sweden
(author)
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Halfvarson, Jonas,1970-Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jshn
(author)
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Reinisch, WalterDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
(author)
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Tysk, Curt,1949-Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University Hospital(Swepub:oru)ctk
(author)
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Department of Medicine, Skaraborgs hospital, Lidköping, SwedenDepartment of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
(creator_code:org_t)
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In:Inflammatory Bowel Diseases: John Wiley & Sons18:2, s. 212-2181078-09981536-4844
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Sjöberg, Mats, 1 ...
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Walch, Andrea
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Hellström, Per M ...
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Gustavsson, Ande ...
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Järnerot, Gunnar
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Vogelsang, Haral ...
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Hertervig, Erik
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Novacek, Gottfri ...
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Angelberger, Sie ...
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Karlén, Per
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Granno, Christer
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Vilien, Mogens
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Ström, Magnus
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Verbaan, Hans
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Hellström, Per M ...
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Dejaco, Clemens
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