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Elution of antitran...
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Rathsman, SandraDepartment of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden
(author)
Elution of antitransglutaminase antibodies from duodenal biopsies : a novel approach in the diagnosis of celiac disease
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-03-24
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Hoboken, USA :Wiley-Blackwell,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-24221
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-24221URI
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https://doi.org/10.1111/j.1600-0463.2012.02884.xDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Celiac disease (CeD) is a disease more prevalent and multisymptomatic than was earlier recognized. Whereas prompt initiation of gluten-free diet (GFD) is beneficial in relieving the symptoms, an accurate CeD diagnosis is necessary also to avoid years of restricted diet on uncertain grounds. We propose a new diagnostic method, based on elution of deposited antibodies against transglutaminase (anti-tTG) from duodenal biopsies in patients with symptoms and screening serology analyses suggestive of CeD. The eluates were analyzed in a Phadia 250 fluoroimmunoassay, demonstrating elevated concentrations of anti-tTG in CeD patients, corresponding to serology and histopathology findings. In one case histology was inconclusive, displaying only unspecific inflammation, but eluted anti-tTG was positive. This patient has clinically improved following GFD. We conclude that our novel method represents a new tool in the diagnostic work up in CeD. The detection of deposited anti-tTG at the site of inflammation appears to provide a high sensitivity and specificity using a technique that is quick, simple and reliable. Further studies are needed for optimization and elucidation of suitable applications for this elution method.
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Tysk, Curt,1949-Örebro universitet,Institutionen för hälsovetenskap och medicin,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden(Swepub:oru)ctk
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Eriksson, SuneDepartment of Laboratory Medicine/Pathology, Örebro University Hospital, Örebro, Sweden
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Hultgren, Olof,1970-Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)ovhn
(author)
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Åberg, Anna-KarinDepartment of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden
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Olcén, PerDepartment of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden
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Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, SwedenInstitutionen för hälsovetenskap och medicin
(creator_code:org_t)
Related titles
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In:Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)Hoboken, USA : Wiley-Blackwell120:8, s. 666-6740903-46411600-0463
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