SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:oru-24333"
 

Search: onr:"swepub:oai:DiVA.org:oru-24333" > HIV, Chlamydia trac...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

HIV, Chlamydia trachomatis and Helicobacter pylori vaccine antigen and proteinaceous adjuvant production in arabidopsis and carrot

Strid, Åke, 1960- (author)
Örebro universitet,Akademin för naturvetenskap och teknik,Biokemi
Lindh, Ingrid (author)
Örebro universitet,Akademin för naturvetenskap och teknik,Biokemi
Kalbina, Irina, 1961- (author)
Örebro universitet,Akademin för naturvetenskap och teknik,Biokemi
show more...
Engstrand, Lars (author)
Smittskyddsinstitutet, The Public Health Agency, Solna, Sweden
Lycke, Nils (author)
Gothenburg University, Gothenburg, Sweden
Marks, Ellen (author)
Gothenburg University, Gothenburg, Sweden
Applequist, Steve (author)
Karolinska Institute, Stockholm, Sweden
Andersson, Sören, 1957- (author)
Örebro University Hospital, Örebro, Sweden
show less...
 (creator_code:org_t)
Bryssel : COST, 2010
2010
English.
In: Molecular farming. - Bryssel : COST. ; , s. 17-17
  • Conference paper (peer-reviewed)
Abstract Subject headings
Close  
  • In our project, we use plants for synthesis of vaccine antigens and adjuvant proteins. Among targeted diseases are HIV, Chlamydia trachomatis (CT) and Helicobacter pylori (HP) infections. Novel genetic constructs have been designed for production of optimized antigen proteins and several transformation techniques and intracellular protein production sites are being examined for yield optimization. Both Arabidopsis thaliana (HIV, CT, HP) and carrot (HIV, CT) have been successfully used as production hosts and plant-produced antigens against HIV (primarily the p24 protein), CT (own designed chimera of the MOMP protein) and HP (different versions of the TonB protein). For HIV and CT these antigens have been used in immunization trials in laboratory mice, giving rise to systemic immune responses. For this purpose both consumption of plant tissue and distribution of purified antigens have been used. For CT, the administration of the recombinant protein has also been shown to protect against the disease in mice. Moreover, to further increase the effect of vaccine antigens, we also use plants to produce protein-based adjuvants for inclusion in vaccine formulations. These adjuvants are based either on the bacterial flagellin protein or are cholera toxin-derived chimeric proteins.

Subject headings

LANTBRUKSVETENSKAPER  -- Bioteknologi med applikationer på växter och djur -- Växtbioteknologi (hsv//swe)
AGRICULTURAL SCIENCES  -- Agricultural Biotechnology -- Plant Biotechnology (hsv//eng)

Keyword

Biochemistry
Biokemi

Publication and Content Type

ref (subject category)
kon (subject category)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view