Search: onr:"swepub:oai:DiVA.org:oru-25784" >
Training at high ex...
Training at high exercise intensity promotes qualitative adaptations of mitochondrial function in human skeletal muscle
-
- Daussin, Frederic (author)
- University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE,UPRES E.A. 3072
-
- Zoll, Joffrey (author)
- University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE,UPRES E.A. 3072
-
- Ponsot, Elodie, 1973- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Muscle & Exercise Physiology Research Group, RISPA
-
show more...
-
- Dufour, Stephane (author)
- Faculty of Sport Sciences, University of Strasbourg, Strasbourg, FRANCE
-
- Doutreleau, Stephane (author)
- Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, FRANCE
-
- Lonsdorfer, Evelyne (author)
- Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, FRANCE
-
- Ventura-Clapier, Renée (author)
- Inserm UMR-S 769, LabEx LERMIT, Châtenay-Malabry, F-92296, France.
-
Mettauer, Bertrand (author)
-
- Piquard, Francois (author)
- University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE,UPRES E.A. 3072
-
- Geny, Bernard (author)
- University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE,UPRES E.A. 3072
-
Richard, Ruddy (author)
-
show less...
-
University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE UPRES EA. 3072 (creator_code:org_t)
- American Physiological Society, 2008
- 2008
- English.
-
In: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 104:5, s. 1436-1441
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- This study explored mitochondrial capacities to oxidize carbohydrate and fatty acids and functional optimization of mitochondrial respiratory chain complexes in athletes who regularly train at high exercise intensity (ATH, n = 7) compared with sedentary (SED, n = 7). Peak O(2) uptake (Vo(2max)) was measured, and muscle biopsies of vastus lateralis were collected. Maximal O(2) uptake of saponin-skinned myofibers was evaluated with several metabolic substrates [glutamate-malate (V(GM)), pyruvate (V(Pyr)), palmitoyl carnitine (V(PC))], and the activity of the mitochondrial respiratory complexes II and IV were assessed using succinate (V(s)) and N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride (V(TMPD)), respectively. Vo(2max) was higher in ATH than in SED (57.8 +/- 2.2 vs. 31.4 +/- 1.3 ml.min(-1).kg(-1), P < 0.001). V(GM) was higher in ATH than in SED (8.6 +/- 0.5 vs. 3.3 +/- 0.3 micromol O(2).min(-1).g dry wt(-1), P < 0.001). V(Pyr) was higher in ATH than in SED (8.7 +/- 1.0 vs. 5.5 +/- 0.2 micromol O(2).min(-1).g dry wt(-1), P < 0.05), whereas V(PC) was not significantly different (5.3 +/- 0.9 vs. 4.4 +/- 0.5 micromol O(2).min(-1).g dry wt(-1)). V(S) was higher in ATH than in SED (11.0 +/- 0.6 vs. 6.0 +/- 0.3 micromol O(2).min(-1).g dry wt(-1), P < 0.001), as well as V(TMPD) (20.1 +/- 1.0 vs. 16.2 +/- 3.4 micromol O(2).min(-1).g dry wt(-1), P < 0.05). The ratios V(S)/V(GM) (1.3 +/- 0.1 vs. 2.0 +/- 0.1, P < 0.001) and V(TMPD)/V(GM) (2.4 +/- 1.0 vs. 5.2 +/- 1.8, P < 0.01) were lower in ATH than in SED. In conclusion, comparison of ATH vs. SED subjects suggests that regular endurance training at high intensity promotes the enhancement of maximal mitochondrial capacities to oxidize carbohydrate rather than fatty acid and induce specific adaptations of the mitochondrial respiratory chain at the level of complex I.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- Sports Science
- Idrottsvetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Daussin, Frederi ...
-
Zoll, Joffrey
-
Ponsot, Elodie, ...
-
Dufour, Stephane
-
Doutreleau, Step ...
-
Lonsdorfer, Evel ...
-
show more...
-
Ventura-Clapier, ...
-
Mettauer, Bertra ...
-
Piquard, Francoi ...
-
Geny, Bernard
-
Richard, Ruddy
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Sport and Fitnes ...
- Articles in the publication
-
Journal of appli ...
- By the university
-
Örebro University