A miRNA expression signature that separates between normal and malignant prostate tissues

Carlsson, Jessica,1984-Högskolan i Skövde,Örebro universitet,Hälsoakademin,Tumörbiologi, Bioinformatik,Institutionen för vård och natur,Forskningscentrum för Systembiologi (author)

BackgroundMicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cancer. In this study we aimed to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues.ResultsNine miRNAs were found to be differentially expressed (p <0.00001). With the exception of two samples, this expression signature could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature. We also identified 16 miRNAs that possibly could be used as a complement to current methods for grading of prostate tumor tissues.ConclusionsWe found an expression signature based on nine differentially expressed miRNAs that with high accuracy (85%) could classify the normal and malignant prostate tissues in patients from the Swedish Watchful Waiting cohort. The results show that there are significant differences in miRNA expression between normal and malignant prostate tissue, indicating that these small RNA molecules might be important in the biogenesis of prostate cancer and potentially useful for clinical diagnosis of the disease.

Davidsson, SabinaÖrebro universitet,Hälsoakademin,Orebro Univ Hosp, Dept Urol, Orebro, Sweden / Univ Orebro, Sch Hlth & Med Sci, Orebro, Sweden(Swepub:oru)sdn (author)
Helenius, GiselaÖrebro universitet,Institutionen för läkarutbildning,Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden(Swepub:oru)ghs (author)
Karlsson, Mats,1960-Örebro universitet,Institutionen för läkarutbildning,Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden(Swepub:oru)mskn (author)
Lubovac, ZelminaHögskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi(Swepub:his)lubz (author)
Andrén, OveÖrebro universitet,Institutionen för läkarutbildning,Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Dept Urol, Orebro, Sweden(Swepub:oru)oan (author)
Olsson, BjörnHögskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi(Swepub:his)olsb (author)
Klinga-Levan, KarinHögskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi(Swepub:his)klik (author)
Örebro universitetHälsoakademin (creator_code:org_t)

By the author/editor: Carlsson, Jessic ...; Davidsson, Sabin ...; Helenius, Gisela; Karlsson, Mats, ...; Lubovac, Zelmina; Andrén, Ove; show more...; Olsson, Björn; Klinga-Levan, Ka ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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