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Dietary fatty acid ...
Dietary fatty acid intake and prostate cancer survival in Örebro county, Sweden
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Epstein, Mara M (author)
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Kasperzyk, Julie L (author)
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Mucci, Lorelei A (author)
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Giovannucci, Edward (author)
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Price, Alkes (author)
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- Wolk, Alicja (author)
- Karolinska Institutet
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- Håkansson, Niclas (author)
- Karolinska Institutet
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- Fall, Katja (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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Andersson, Swen-Olof (author)
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Andrén, Ove (author)
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(creator_code:org_t)
- 2012-07-10
- 2012
- English.
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In: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 176:3, s. 240-252
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Although dietary fat has been associated with prostate cancer risk, the association between specific fatty acids and prostate cancer survival remains unclear. Dietary intake of 14 fatty acids was analyzed in a population-based cohort of 525 Swedish men with prostate cancer in Örebro County (1989-1994). Multivariable hazard ratios and 95% confidence intervals for time to prostate cancer death by quartile and per standard deviation increase in intake were estimated by Cox proportional hazards regression. Additional models examined the association by stage at diagnosis (localized: T0-T2/M0; advanced: T0-T4/M1, T3-T4/M0). Among all men, those with the highest omega-3 docosahexaenoic acid and total marine fatty acid intakes were 40% less likely to die from prostate cancer (P(trend) = 0.05 and 0.04, respectively). Among men with localized prostate cancer, hazard ratios of 2.07 (95% confidence interval: 0.93, 4.59; P(trend) = 0.03) for elevated total fat, 2.39 (95% confidence interval: 1.06, 5.38) for saturated myristic acid, and 2.88 (95% confidence interval: 1.24, 6.67) for shorter chain (C4-C10) fatty acid intakes demonstrated increased risk for disease-specific mortality for the highest quartile compared with the lowest quartile. This study suggests that high intake of total fat and certain saturated fatty acids may worsen prostate cancer survival, particularly among men with localized disease. In contrast, high marine omega-3 fatty acid intake may improve disease-specific survival for all men.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Epstein, Mara M
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Kasperzyk, Julie ...
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Mucci, Lorelei A
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Giovannucci, Edw ...
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Price, Alkes
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Wolk, Alicja
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show more...
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Håkansson, Nicla ...
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Fall, Katja
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Andersson, Swen- ...
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Andrén, Ove
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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American Journal ...
- By the university
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Örebro University
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Karolinska Institutet