Infection induced chronic inflammation and it's association with prostate cancer initiation and progression

Davidsson, Sabina, 1972- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin

Andrén, Ove, Professor (thesis advisor): Örebro universitet,Institutionen för hälsovetenskap och medicin

Söderquist, Bo, Professor (thesis advisor): Örebro universitet,Institutionen för läkarutbildning

Rider, Jennifer, ScD (thesis advisor): Örebro University Hospital, Sweden Department of Epidemiology, Harvard School Of Public Health; Department of Medicine, Harvard Medical School

Helenius, Gisela, Associate Professor (thesis advisor): Örebro universitet,Institutionen för hälsovetenskap och medicin

(creator_code:org_t)

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Abstract Subject headings

An association between cancer development and inflammation has long been suggested. Approximately 20% of all human cancers in adults are assumed to result from chronic inflammation. The aim of this thesis was to investigate if infection-induced chronic inflammation plays a role in prostate carcinogenesis.Our results revealed a greater infiltration of the bacterium Propionibacterium acnes in the prostate tissue obtained from men with prostate cancer compared to men without any histological evidence of the disease. These findings indicate that prostate cancer could potentially be included in the list of cancers with an infectious etiology.Further, we investigated whether chronic inflammation has a role in disease progression. Our results demonstrated that men with lethal prostate cancer had pronounced infiltration of immune cells with suppressive function of the anti-tumor immune response compared to men with a more indolent prostate cancer.Confirmation of our results may open up avenues for targeted prostate cancer treatment by offering men with chronic inflammation alternative therapies such as anti-inflammatory drugs. If the involvement of P. acnes in prostate cancer development is replicated in other studies, vaccination therapies may be feasible. To further individualize prostate cancer therapy, bolstering the anti-tumor immune response in order to reduce tumor progression may be determined to be advantageous for some patients.

By the author/editor: Davidsson, Sabin ...; Andrén, Ove, Pro ...; Söderquist, Bo, ...; Rider, Jennifer, ...; Helenius, Gisela ...; Damber, Jan-Erik ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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