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ERG Rearrangement M...
ERG Rearrangement Metastasis Patterns in Locally Advanced Prostate Cancer
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Perner, Sven (author)
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- Svensson, Maria A. (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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Hossain, Ruhella R. (author)
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Day, John R. (author)
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Groskopf, Jack (author)
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Slaughter, Ryan C. (author)
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Jarleborn, Analee R. (author)
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Hofer, Matthias D. (author)
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Kuefer, Rainer (author)
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Demichelis, Francesca (author)
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Rickman, David S. (author)
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- Rubin, Mark A. (author)
- Inst Computat Biomed, Weill Cornell Med Coll, New York NY, USA
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Urology. - : Elsevier BV. - 0090-4295 .- 1527-9995. ; 75:4, s. 762-767
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVES To interrogate multifocal prostate cancer (PCa) to determine its predilection for metastasis, using ERG rearrangement as marker of clonality. A hallmark of PCa is that distinct tumor foci may arise independently, which has important biological and clinical implications. Recent studies characterizing ERG-rearranged PCa possessing intrafocal homogeneity but interfocal heterogeneity support this hypothesis. METHODS We studied 26 patients who underwent prostatectomy and lymphadenectomy with at least 2 distinct PCa foci and 1 lymph node (LN) metastasis. Each focus was assessed for size, Gleason score, ERG rearrangement, and TMPRSS2-ERG transcript. RESULTS Fifteen of 26 cases exhibited interfocal homogeneity with regard to ERG rearrangement (ie, presence vs absence of ERG rearrangement). ERG rearrangement was present in all foci for 6 and absent in all foci for 9 cases. Two cases revealed interfocal heterogeneity with regard to rearrangement mechanism ( ie, rearrangement through insertion or deletion). Eight of 26 cases revealed interfocal heterogeneity with regard to rearrangement status. In all cases with at least 1 ERG rearranged focus, we found the corresponding LN metastasis harboring an ERG rearrangement. Interestingly, in a subset of cases the rearrangement status in the LN did not correspond to size or Gleason score. All but 2 ERG rearranged foci had detectable TMPRSS2-ERG transcript levels. CONCLUSIONS When multifocal PCa demonstrates both ERG-positive and ERG-negative foci, the positive foci have a greater predilection for metastasis. Larger studies are needed to confirm the potential additional risk an ERG rearranged focus confers on the likelihood of disease progression. UROLOGY 75: 762-767, 2010. (C) 2010 Elsevier Inc.
Keyword
- Medicine
- Medicin
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- ref (subject category)
- art (subject category)
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Urology
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- By the author/editor
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Perner, Sven
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Svensson, Maria ...
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Hossain, Ruhella ...
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Day, John R.
-
Groskopf, Jack
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Slaughter, Ryan ...
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show more...
-
Jarleborn, Anale ...
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Hofer, Matthias ...
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Kuefer, Rainer
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Demichelis, Fran ...
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Rickman, David S ...
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Rubin, Mark A.
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show less...
- Articles in the publication
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Urology
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Örebro University