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Biotransformation o...
Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans
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- Nilsson, Helena, 1974- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM
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- Kärrman, Anna, 1975- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM
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- Rotander, Anna, 1978- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM
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- Lindström, Gunilla, 1949- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM
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- Westberg, Håkan, 1949- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Region Örebro län
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(creator_code:org_t)
- Elsevier, 2013
- 2013
- English.
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In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 51, s. 8-12
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Levels of perfluorocarboxylates (PFCAs) in biological compartments have been known for some time but their transport routes and distribution patterns are not properly elucidated. The opinions diverge whether the exposure of the general population occurs indirect through precursors or direct via PFCAs. Previous results showed that ski wax technicians are exposed to levels up to 92 000 ng/m(3) of 8:2 fluorotelomer alcohol (FTOH) via air and have elevated blood levels of PFCAs. Blood samples were collected in 2007-2011 and analyzed for C(4)-C(18) PFCAs, 6:2, 8:2 and 10:2 unsaturated fluorotelomer acids (FTUCAs) and 3:3, 5:3 and 7:3 fluorotelomer acids (FTCAs) using UPLC-MS/MS. Perfluorooctanoic acid (PFOA) was detected in levels ranging from 1.90 to 628 ng/mL whole blood (wb). Metabolic intermediates 5:3 and 7:3 FTCA were detected in all samples at levels up to 6.1 and 3.9 ng/mL wb. 6:2, 8:2 and 10:2 FTUCAs showed maximum levels of 0.07, 0.64 and 0.11 ng/mL wb. Also, for the first time levels of PFHxDA and PFOcDA were detected in the human blood at mean concentrations up to 4.22 ng/mL wb and 4.25 ng/mL wb respectively. The aim of this study was to determine concentrations of PFCAs and FTOH metabolites in blood from ski wax technicians.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- Chemistry
- Kemi
- Miljökemi
- Environmental Chemistry
- Biology
- Biologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nilsson, Helena, ...
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Kärrman, Anna, 1 ...
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Rotander, Anna, ...
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van Bavel, Bert, ...
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Lindström, Gunil ...
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Westberg, Håkan, ...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
- Articles in the publication
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Environment Inte ...
- By the university
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Örebro University