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- Almon, Ricardo,1965-Örebro universitet,Institutionen för hälsovetenskap och medicin (author)
Association of the European lactase persistence variant (LCT-13910 C > T Polymorphism) with obesity in the Canary Islands
- Article/chapterEnglish2012
Publisher, publication year, extent ...
- 2012-08-24
- San Francisco :Public Library Science,2012
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:oru-29769
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-29769URI
- https://doi.org/10.1371/journal.pone.0043978DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Background: European lactose tolerance genotype (LCT -13910 C>T, rs4988234) has been positively associated to body mass indexes (BMI) in a meta-analysis of 31,720 individuals of northern and central European descent. A strong association of lactase persistence (LP) with BMI and obesity has also been traced in a Spanish Mediterranean population. The aim of this study was to analyze a potential association of LP compared to lactase non-persistence (LNP) with BMI in inhabitants of the Canary Islands of Spain using Mendelian randomization.Methods: A representative, randomly sampled population of adults belonging to the Canary Islands Nutrition Survey (ENCA) in Spain, aged 18-75 years (n = 551), was genotyped for the LCT - 13910 C>T polymorphism. Milk consumption was assessed by a validated questionnaire. Anthropometric variables were directly measured. WHO classification of BMI was used.Results: LP individuals were significantly more obese than LNP subjects (chi(2) = 10.59; p < 0.005). LP showed in a multivariate linear regression analysis showed a positive association of LP with BMI compared to LNP, (beta = 0.96; 95% CI: 0.08-1.85, p = 0.033). In a multinomial logistic regression analysis normal range weight LP subjects showed an odds ratio for obesity of 2.41; 95% CI 1.39-418, (p = 0.002) compared to LNP.Conclusions: The T-13910 of the allele LCT-13910 C>T polymorphism is positively associated with BMI. LP increases significantly the risk to develop obesity in the studied population. The LCT-13910 C>T polymorphism stands proxy for the lifetime exposure pattern, milk intake, that may increase susceptibility to obesity and to obesity related pathologies.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
- Medicin
- Medicine
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- Alvarez-Leon, Elisa EvaPreventive Medicine Service, Canary Health Service, Department of Clinical Sciences, Faculty of Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain (author)
- Serra-Majem, LluisPreventive Medicine Service, Canary Health Service, Department of Clinical Sciences, Faculty of Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain (author)
- Örebro universitetInstitutionen för hälsovetenskap och medicin (creator_code:org_t)
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- In:PLOS ONESan Francisco : Public Library Science7:81932-6203
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