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Coffee consumption ...
Coffee consumption and risk of localized, advanced and fatal prostate cancer : a population-based prospective study
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- Discacciati, A. (author)
- Karolinska Institutet
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- Orsini, N. (author)
- Karolinska Institutet
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- Andersson, Swen-Olof (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Urology, Örebro University Hospital, Örebro, Sweden
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- Andrén, Ove (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Urology, Örebro University Hospital, Örebro, Sweden,Univ Orebro, Sch Hlth & Med Sci, Orebro, Sweden.;Orebro Univ Hosp, Dept Urol, Orebro, Sweden.
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- Johansson, Jan-Erik (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Urology, Örebro University Hospital, Örebro, Sweden
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- Mantzoros, C. S. (author)
- Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States; Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, United States,Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Endocrinol Sect, Boston VA Healthcare Syst, Boston, MA USA.
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- Wolk, A. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 24:7, s. 1912-1918
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http://www.annalsofo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: The epidemiological evidence on possible relationships between coffee consumption and prostate cancer (PCa) risk by subtype of the disease (localized, advanced) and fatal PCa risk is limited.Materials and methods: A population-based cohort of 44 613 Swedish men aged 45-79 years was followed up from January 1998 through December 2010 for incidence of localized (n = 2368), advanced (n = 918) and fatal (n = 515) PCa. We assessed the associations between coffee consumption and localized, advanced and fatal PCa risk using competing-risk regressions. We examined possible effect modification by body mass index (BMI).Results: For localized PCa, each one cup increase in daily coffee consumption was associated with a 3% reduced risk [sub-hazard ratio (SHR) = 0.97, 95% confidence interval (CI) = 0.95-0.99]. For advanced and fatal PCa, we found a non-significant inverse association; each one cup increase was associated with a 2% reduced risk of advanced [SHR (95% CI) = 0.98 (0.95-1.02)] and fatal PCa [SHR (95% CI) = 0.98 (0.93-1.03)]. We observed evidence of effect modification by BMI for localized PCa (P-interaction = 0.03); the inverse association was stronger among overweight and obese men (BMI >= 25 kg/m(2)) compared with normal-weight men (BMI < 25 kg/m(2)).Conclusions: We observed a clear inverse association between coffee consumption and risk of localized PCa, especially among overweight and obese men.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- coffee
- epidemiology
- prospective cohort study
- prostate cancer
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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