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Global DNA hypermet...
Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population
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- Lind, Lars (author)
- Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Uppsala, Sweden
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- Penell, Johanna (author)
- Uppsala universitet,Arbets- och miljömedicin,Uppsala University, Uppsala, Sweden
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- Luttropp, Karin (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Nordfors, Louise (author)
- Karolinska Institutet, Stockholm, Sweden
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala, Sweden
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- Axelsson, Tomas (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala, Sweden
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- Salihovic, Samira (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- van Bavel, Bert (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Fall, Tove (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala, Sweden
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala, Sweden
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- Lind, P Monica (author)
- Uppsala universitet,Arbets- och miljömedicin,Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 59, s. 456-461
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Abstract
Subject headings
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- Dioxin exposure has experimentally been associated with changes in DNA methylation, an epigenetic change that is associated with disease. The present study aims to investigate if serum levels of dioxin and other persistent environmental pollutants are related to global DNA methylation in a human sample. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (all aged 70), global DNA methylation was measured by the Luminometric Methylation Assay in 524 subjects. Twenty-three different POPs, including 16 PCBs, five pesticides, one dioxin (OCDD) and one brominated flame retardant (BDE47) were analysed by HRGC/HRMS. Ten single nucleotide polymorphisms (SNPs) in the Aryl hydrocarbon (Ah)-receptor were analysed by mini-sequencing. High levels of toxic equivalency (TEQ) for PCBs and dioxin were associated with DNA hypermethylation (p = 0.030). This was mainly attributed to coplanar non-ortho PCBs. While no significant associations were found between DNA methylation and SNPs in the Ah-receptor, an interaction was found between the SNP rs2237297 and TEQ so that TEQ was associated with hypermethylation (p = 0.009) only in subjects with one G-allele (n = 103). Also high levels of the PCB126 congener, the OCDD, and the pesticide metabolite p,p'-DDE were related to DNA hypermethylation (p = 0.01, 0.03 and 0.003, respectively). In conclusion, in a sample of elderly subjects, high TEQ including PCBs and the dioxin OCDD and high serum levels of PCB126, OCDD, and p,p'-DDE were related to global DNA hypermethylation in a cross-sectional analysis. (C) 2013 Elsevier Ltd. All rights reserved.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- DNA methylation
- Persistent organic pollutants
- Elderly
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lind, Lars
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Penell, Johanna
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Luttropp, Karin
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Nordfors, Louise
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Syvänen, Ann-Chr ...
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Axelsson, Tomas
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show more...
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Salihovic, Samir ...
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van Bavel, Bert
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Fall, Tove
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Ingelsson, Erik
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Lind, P Monica
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Environment Inte ...
- By the university
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Örebro University
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Uppsala University
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Karolinska Institutet