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Multiresistant urop...
Multiresistant uropathogenic extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are susceptible to the carbon monoxide releasing molecule-2 (CORM-2).
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- Bang, Charlotte Sahlberg, 1967- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Kruse, Robert, 1972- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län
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- Demirel, Isak, 1987- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Önnberg, Anna, 1980- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Dept Lab Med, Örebro University Hospital, Örebro, Sweden
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- Söderquist, Bo, 1955- (author)
- Örebro universitet,Institutionen för läkarutbildning,Region Örebro län,Dept Lab Med, Örebro University Hospital, Örebro, Sweden
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- Persson, Katarina, 1962- (author)
- Örebro universitet,Institutionen för läkarutbildning
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(creator_code:org_t)
- London : Elsevier, 2014
- 2014
- English.
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In: Microbial Pathogenesis. - London : Elsevier. - 0882-4010 .- 1096-1208. ; 66, s. 29-35
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Carbon monoxide (CO) releasing molecules (CO-RMs) have been shown to inhibit growth of commensal Escherichia coli (E. coli). In the present study we examined the effect of CORM-2 on uropathogenic E. coli (UPEC) that produces extended-spectrum β-lactamase (ESBL). Viability experiments showed that CORM-2 inhibited the growth of several different ESBL-producing UPEC isolates and that 500 μM CORM-2 had a bactericidal effect within 4 h. The bactericidal effect of CORM-2 was significantly more pronounced than the effect of the antibiotic nitrofurantoin. CORM-2 demonstrated a low level of cytotoxicity in eukaryotic cells (human bladder epithelial cell line 5637) at the concentrations and time-points where the antibacterial effect was obtained. Real-time RT-PCR studies of different virulence genes showed that the expression of capsule group II kpsMT II and serum resistance traT was reduced and that some genes encoding iron acquisition systems were altered by CORM-2. Our results demonstrate that CORM-2 has a fast bactericidal effect against multiresistant ESBL-producing UPEC isolates, and also identify some putative UPEC virulence factors as targets for CORM-2. CO-RMs may be candidate drugs for further studies in the field of finding new therapeutic approaches for treatment of uropathogenic ESBLproducing E. coli.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Carbon monoxide; CORM-2; Extended-spectrum β-lactamases; Uropathogenic E. coli; CTX-M
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bang, Charlotte ...
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Kruse, Robert, 1 ...
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Demirel, Isak, 1 ...
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Önnberg, Anna, 1 ...
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Söderquist, Bo, ...
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Persson, Katarin ...
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Örebro University