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The Vasa Vasorum an...
The Vasa Vasorum and Associated Endothelial Nitric Oxide Synthase is More Important for Saphenous Vein Than Arterial Bypass Grafts
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- Dreifaldt, Mats (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Thoracic and Cardiovascular Surgery, Örebro University Hospital, Region rebro County, Örebro, Sweden
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- Souza, Domingos S. R. (author)
- Department of Thoracic and Cardiovascular Surgery, Örebro University Hospital, Region Örebro County, Örebro, Sweden
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- Bodin, Lennart (author)
- Karolinska Institutet
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- Shi-Wen, Xu (author)
- Department of Rheumatology, Royal Free and University College Medical School, London, UK
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- Dooley, Audrey (author)
- Department of Rheumatology, Royal Free and University College Medical School, London, UK
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- Muddle, John (author)
- Department of Neurological Science, Royal Free and University College Medical School, London, UK
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- Loesch, Andrzej (author)
- Division of Medicine, Royal Free and University College Medical School, London, UK
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- Dashwood, Michael R. (author)
- Division of Medicine, Royal Free and University College Medical School, London, UK
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(creator_code:org_t)
- 2012-05-07
- 2013
- English.
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In: Angiology. - : SAGE Publications. - 0003-3197 .- 1940-1574. ; 64:4, s. 293-299
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- No-touch (NT) saphenous vein (SV) grafts are superior to SVs harvested by the conventional technique (CT), with a patency comparable with the internal thoracic artery (ITA). Preservation of the vasa vasorum is implicated in the success of NT harvesting. We compared the vasa vasorum and endothelial nitric oxide synthase (eNOS) in NT SV with ITA and radial artery (RA) grafts. Skeletonized SV (SSV) was also analyzed. The NT SV had a higher number and larger vasa vasorum compared with ITA (P = .0001) and RA (P = .0004) that correlated with eNOS protein. Activity of eNOS in SSV grafts was significantly lower than NT SV grafts (P = 004). Since a high proportion of the vasa vasorum are removed in SSV using the CT, we suggest that preservation of the vasa vasorum and eNOS-derived NO contributes to the high patency for NT as compared with SSV grafts.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- coronary artery bypass surgery
- saphenous vein
- internal thoracic artery
- radial artery
- vasa vasorum
- endothelial nitric oxide synthase
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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