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Subclinical Inflamm...
Subclinical Inflammation with Increased Neutrophil Activity in Healthy Twin Siblings Reflect Environmental Influence in the Pathogenesis of Inflammatory Bowel Disease
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- Zhulina, Yaroslava, 1973- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden
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- Hahn-Strömberg, Victoria, 1971- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Pathology, Örebro University Hospital, Örebro, Sweden; Department of Clinical Medicine, Örebro University, Örebro, Sweden
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- Shamikh, Alia (author)
- Karolinska Institutet
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- Peterson, Christer G. B. (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Gustavsson, Anders, 1964- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Nyhlin, Nils, 1971- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden
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- Wickbom, Anna, 1970- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Bohr, Johan, 1957- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden
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- Bodin, Lennart, 1941- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Institute of Environmental Medicine, Unit of Intervention and Implementation Research, Karolinska Institute, Stockholm, Sweden
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- Tysk, Curt, 1949- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden
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- Carlson, Marie (author)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för läkarutbildning,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden
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(creator_code:org_t)
- Philadelphia, USA : Lippincott Williams & Wilkins, 2013
- 2013
- English.
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In: Inflammatory Bowel Diseases. - Philadelphia, USA : Lippincott Williams & Wilkins. - 1078-0998 .- 1536-4844. ; 19:8, s. 1725-1731
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: The mechanisms behind increased fecal calprotectin (FC) in healthy relatives of patients with inflammatory bowel disease (IBD) are unknown. Our aims were to explore if there is a subclinical inflammation with increased neutrophil activity in healthy twin siblings in discordant twin pairs with IBD and to assess the influence of genetics in this context.Methods: Nuclear factor kappa B (NF-B) and neutrophil activity, based on myeloperoxidase (MPO) and FC, were analyzed in healthy twin siblings in discordant twin pairs with IBD and compared with healthy controls. NF-B and MPO were assessed by immunohistochemistry and FC by enzyme-linked immunosorbent assay.Results: In total, 33 of 34 healthy twin siblings were histologically normal. Increased NF-B was more often observed in healthy twin siblings in discordant twin pairs with Crohn's disease (13/18 [73%]) and with ulcerative colitis (12/16 [75%]) than in healthy controls (8/45 [18%]). MPO was more often increased in healthy twin siblings in discordant pairs with Crohn's disease (12/18 [67%]) than in healthy controls (11/45 [24%]) and FC more often in healthy twin siblings in discordant pairs with ulcerative colitis (14/21 [67%]) than in healthy controls (6/31 [19%]). Interestingly, the observed differences remained when healthy monozygotic and dizygotic twin siblings were analyzed separately.Conclusions:We observed increased NF-B, MPO, and FC in healthy twins in both monozygotic and dizygotic discordant pairs with IBD. These novel findings speak for an ongoing subclinical inflammation with increased neutrophil activity in healthy first-degree relatives.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Inflammatory bowel disease
- twins
- genetics
- subclinical activity
- nuclear factor-kappa B
- myeloperoxidase
- F-calprotectin
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Zhulina, Yarosla ...
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Hahn-Strömberg, ...
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Shamikh, Alia
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Peterson, Christ ...
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Gustavsson, Ande ...
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Nyhlin, Nils, 19 ...
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Wickbom, Anna, 1 ...
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Bohr, Johan, 195 ...
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Bodin, Lennart, ...
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Tysk, Curt, 1949 ...
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Carlson, Marie
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Halfvarson, Jona ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Gastroenterology ...
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MEDICAL AND HEAL ...
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Inflammatory Bow ...
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Örebro University
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Karolinska Institutet
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Uppsala University