Search: onr:"swepub:oai:DiVA.org:oru-33716" > Subclinical Inflamm...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06883naa a2200637 4500 | |
001 | oai:DiVA.org:oru-33716 | |
003 | SwePub | |
008 | 140212s2013 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:128031952 | |
009 | oai:DiVA.org:uu-217688 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-337162 URI |
024 | 7 | a https://doi.org/10.1097/MIB.0b013e318281f2d32 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1280319522 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2176882 URI |
040 | a (SwePub)orud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Zhulina, Yaroslava,d 1973-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden4 aut0 (Swepub:oru)yza |
245 | 1 0 | a Subclinical Inflammation with Increased Neutrophil Activity in Healthy Twin Siblings Reflect Environmental Influence in the Pathogenesis of Inflammatory Bowel Disease |
264 | 1 | a Philadelphia, USA :b Lippincott Williams & Wilkins,c 2013 |
338 | a electronic2 rdacarrier | |
500 | a Funding Agencies:Bengt Ihre's foundation Nanna Svartz' foundation Orebro University Hospital Research Foundation Orebro County Research Foundation Swedish Foundation for Gastrointestinal research | |
520 | a Background: The mechanisms behind increased fecal calprotectin (FC) in healthy relatives of patients with inflammatory bowel disease (IBD) are unknown. Our aims were to explore if there is a subclinical inflammation with increased neutrophil activity in healthy twin siblings in discordant twin pairs with IBD and to assess the influence of genetics in this context.Methods: Nuclear factor kappa B (NF-B) and neutrophil activity, based on myeloperoxidase (MPO) and FC, were analyzed in healthy twin siblings in discordant twin pairs with IBD and compared with healthy controls. NF-B and MPO were assessed by immunohistochemistry and FC by enzyme-linked immunosorbent assay.Results: In total, 33 of 34 healthy twin siblings were histologically normal. Increased NF-B was more often observed in healthy twin siblings in discordant twin pairs with Crohn's disease (13/18 [73%]) and with ulcerative colitis (12/16 [75%]) than in healthy controls (8/45 [18%]). MPO was more often increased in healthy twin siblings in discordant pairs with Crohn's disease (12/18 [67%]) than in healthy controls (11/45 [24%]) and FC more often in healthy twin siblings in discordant pairs with ulcerative colitis (14/21 [67%]) than in healthy controls (6/31 [19%]). Interestingly, the observed differences remained when healthy monozygotic and dizygotic twin siblings were analyzed separately.Conclusions:We observed increased NF-B, MPO, and FC in healthy twins in both monozygotic and dizygotic discordant pairs with IBD. These novel findings speak for an ongoing subclinical inflammation with increased neutrophil activity in healthy first-degree relatives. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Inflammatory bowel disease | |
653 | a twins | |
653 | a genetics | |
653 | a subclinical activity | |
653 | a nuclear factor-kappa B | |
653 | a myeloperoxidase | |
653 | a F-calprotectin | |
653 | a Medicine | |
653 | a Medicin | |
700 | 1 | a Hahn-Strömberg, Victoria,d 1971-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Pathology, Örebro University Hospital, Örebro, Sweden; Department of Clinical Medicine, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)vhg |
700 | 1 | a Shamikh, Aliau Karolinska Institutet4 aut |
700 | 1 | a Peterson, Christer G. B.u Uppsala universitet,Biokemisk struktur och funktion4 aut0 (Swepub:uu)chpet425 |
700 | 1 | a Gustavsson, Anders,d 1964-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)argn |
700 | 1 | a Nyhlin, Nils,d 1971-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden4 aut0 (Swepub:oru)nnn |
700 | 1 | a Wickbom, Anna,d 1970-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)anwm |
700 | 1 | a Bohr, Johan,d 1957-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden4 aut0 (Swepub:oru)jbr |
700 | 1 | a Bodin, Lennart,d 1941-u Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Institute of Environmental Medicine, Unit of Intervention and Implementation Research, Karolinska Institute, Stockholm, Sweden4 aut0 (Swepub:oru)lbn |
700 | 1 | a Tysk, Curt,d 1949-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden4 aut0 (Swepub:oru)ctk |
700 | 1 | a Carlson, Marieu Uppsala universitet,Gastroenterologi/hepatologi4 aut0 (Swepub:uu)maricarl |
700 | 1 | a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för läkarutbildning,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden4 aut0 (Swepub:oru)jshn |
710 | 2 | a Örebro universitetb Institutionen för hälsovetenskap och medicin4 org |
773 | 0 | t Inflammatory Bowel Diseasesd Philadelphia, USA : Lippincott Williams & Wilkinsg 19:8, s. 1725-1731q 19:8<1725-1731x 1078-0998x 1536-4844 |
856 | 4 | u https://oru.diva-portal.org/smash/get/diva2:695868/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-33716 |
856 | 4 8 | u https://doi.org/10.1097/MIB.0b013e318281f2d3 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:128031952 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-217688 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Copy and save the link in order to return to this view