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Human Gene Variants...
Human Gene Variants Linked to Enhanced NLRP3 Activity Limit Intramacrophage Growth of Mycobacterium tuberculosis
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- Eklund, Daniel, 1984- (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Welin, Amanda, 1983 (author)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Andersson, Henrik (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Verma, Deepti (author)
- Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet
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- Söderkvist, Peter (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik
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- Stendahl, Olle (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Särndahl, Eva, 1963- (author)
- Linköpings universitet,Örebro universitet,Institutionen för läkarutbildning,Avdelningen för cellbiologi,Hälsouniversitetet
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- Lerm, Maria (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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(creator_code:org_t)
- 2013-10-24
- 2014
- English.
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In: Journal of Infectious Diseases. - Cary, USA : Oxford University Press. - 0022-1899 .- 1537-6613. ; 209:5, s. 749-753
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Abstract
Subject headings
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- Activation of the NLRP3 inflammasome and subsequent generation of interleukin 1 beta is initiated in macrophages upon recognition of several stimuli. In the present work, we show that gain-of-function gene variants of inflammasome components known to predispose individuals to inflammatory disorders have a host-protective role during infection with Mycobacterium tuberculosis. By isolation of macrophages from patients and healthy blood donors with genetic variants in NLRP3 and CARD8 and subsequent infection of the cells with virulent M. tuberculosis, we show that these gene variants, combined, are associated with increased control of bacterial growth in human macrophages.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- NLRP3
- CARD8
- inflammasome
- IL-1 beta
- human macrophage
- C10X
- Q705K
- tuberculosis
- mycobacteria
- Immunologi
- Immunology
- NLRP3
- CARD8
- inflammasome
- IL-1β
- human macrophage
- C10X
- Q705K
- tuberculosis
- mycobacteria
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eklund, Daniel, ...
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Welin, Amanda, 1 ...
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Andersson, Henri ...
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Verma, Deepti
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Söderkvist, Pete ...
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Stendahl, Olle
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show more...
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Särndahl, Eva, 1 ...
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Lerm, Maria
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of Infec ...
- By the university
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Örebro University
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University of Gothenburg
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Linköping University