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Circulating levels ...
Circulating levels of p,p '-DDE are related to prevalent hypertension in the elderly
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- Lind, Monica P. (author)
- Uppsala universitet,Arbets- och miljömedicin
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- Penell, Johanna (author)
- Uppsala universitet,Arbets- och miljömedicin
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- Salihovic, Samira, 1985- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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(creator_code:org_t)
- San Diego : Academic Press, 2014
- 2014
- English.
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In: Environmental Research. - San Diego : Academic Press. - 0013-9351 .- 1096-0953. ; 129, s. 27-31
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Polychlorinated biphenyls (PCBs) and dioxin given to experimental animals increase the blood pressure. We therefore investigated if circulating levels of persistent organic pollutants (POPs) were related to hypertension in a population-based sample of men and women.Methods: One thousand and sixteen subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Twenty-three POPs were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Hypertension was defined as a systolic blood pressure >= 140 mmHg or a diastolic blood pressure >= 90 mmHg, and/or use of antihypertensive medication.Results: Seven hundred and thirty-two subjects (72%) showed hypertension. When the POPs were treated as continuous variables and adjusted for gender only, two PCBs with a low number of chlorine atoms (PCB 105 and 118) were related to prevalent hypertension. Also the OC pesticide p,p'-DDE was related to hypertension. The strongest of these associations was seen for p,p'-DDE (OR 135 for a 1 SD change, 95% CI 1.17-1.56, p < 0.0001). Following further adjustment also for BMI, smoking status, education level and exercise habits, only p,p'-DDE was still significantly related to hypertension (OR 1.23 for a 1 SD change, 95% CI 1.06-1.43, p=0.006).Conclusion: In this cross-sectional analysis of an elderly population, high levels of circulating levels of p,p'-DDE were associated with prevalent hypertension, further strengthening the experimental findings that POPs might influence blood pressure. (C) 2013 Elsevier Inc. All rights reserved.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Hypertension
- Elderly
- Persistent organic pollutants
- Polychlorinated biphenyls
- DDE
- Miljökemi
- Environmental Chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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