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Total Antioxidant C...
Total Antioxidant Capacity of the Diet and Risk of Age-Related Cataract A Population-Based Prospective Cohort of Women
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- Rautiainen, Susanne (author)
- Karolinska Institutet
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- Lindblad, Birgitta Ejdervik, 1955- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden,Univ Orebro, Orebro Univ Hosp, Dept Ophthalmol, SE-70182 Orebro, Sweden.
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- Morgenstern, Ralf (author)
- Karolinska Institutet
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- Wolk, Alicja (author)
- Karolinska Institutet
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(creator_code:org_t)
- Chicago : American Medical Association, 2014
- 2014
- English.
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In: JAMA ophthalmology. - Chicago : American Medical Association. - 2168-6165 .- 2168-6173. ; 133:3, s. 247-252
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- IMPORTANCE: To our knowledge, no previous epidemiologic study has investigated the association between all antioxidants in the diet and age-related cataract. The total antioxidant capacity (TAC) concept aims to measure the capacity from all antioxidants in the diet by also taking synergistic effects into account.OBJECTIVE: To investigate the association between the TAC of the diet and the incidence of age-related cataract in a population-based prospective cohort of middle-aged and elderly women.DESIGN, SETTING, AND PARTICIPANTS: Questionnaire-based nutrition survey within the prospective Swedish Mammography Cohort study, which included 30 607 women (aged 49-83 years) who were observed for age-related cataract incidence for a mean of 7.7 years.EXPOSURE: The TAC of the diet was estimated using a database of foods analyzed with the oxygen radical absorbance capacity assay.MAIN OUTCOMES AND MEASURES: Information on incident age-related cataract diagnosis and extraction was collected through linkage to registers in the study area.RESULTS: There were 4309 incident cases of age-related cataracts during the mean 7.7 years of follow-up (234 371 person-years). The multivariable rate ratio in the highest quintile of the TAC of the diet compared with the lowest was 0.87 (95% CI, 0.79-0.96; P for trend = .03). The main contributors to dietary TAC in the study population were fruit and vegetables (44.3%), whole grains (17.0%), and coffee (15.1%).CONCLUSIONS AND RELEVANCE: Dietary TAC was inversely associated with the risk of age-related cataract. Future studies examining all antioxidants in the diet in relation to age-related cataract are needed to confirm or refute our findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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