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- Block, TUppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular surgery (author)
Diagnostic accuracy of plasma biomarkers for intestinal ischaemia
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- 2009-07-08
- Informa UK Limited,2008
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-3510
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3510URI
- https://doi.org/10.1080/00365510701646264DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16613URI
- https://lup.lub.lu.se/record/1139253URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Objective. Intestinal ischaemia is a life‐threatening condition with high mortality, and the lack of accurate and readily available diagnostic methods often results in delay in diagnosis and treatment. The aim of this study was to investigate the accuracy of different plasma biomarkers in diagnosing intestinal ischaemia. Material and methods. Prospective inclusion of patients older than 50 years with acute abdomen admitted to hospital in Karlskrona, Sweden, between 2001 and 2003. Venous blood was sampled prior to any surgery and within 24h from onset of pain. D‐lactate, alpha glutathione S‐transferase, intestinal fatty acid binding protein, creatine kinase B, isoenzymes of lactate dehydrogenase (LD) and alkaline liver phosphatase (ALP) were analysed. D‐dimer was analysed using four different commercially available test kits. Results. In‐hospital mortalities among patients with (n = 10) and without (n = 61) intestinal ischaemia were 40% and 3%, respectively (p = 0.003). D‐dimer was associated with intestinal ischaemia (p = 0.001) independently of which assay was used. No patient presenting with a normal D‐dimer had intestinal ischaemia. D‐dimer >0.9mg/L had a specificity, sensitivity and accuracy of 82%, 60% and 79%, respectively. Total LD, isoenzymes of LD 1–4 and liver isoenzyme of ALP (ALP liver) were significantly higher in patients with intestinal ischaemia, and accuracies for LD 2 (cut‐off 2.3µkat/L) and ALP liver (cut‐off 0.7µkat/L) were 69% and 66%, respectively. Conclusions. D‐dimer may be used as an exclusion test for intestinal ischaemia, but lacks specificity. The other plasma biomarkers studied had insufficient accuracy for this group of patients. Further studies are needed.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
- Aged
- Aged; 80 and over
- Biological Markers/*blood
- Female
- Hospital Mortality
- Humans
- Intestinal Diseases/blood/*diagnosis
- Ischemia/blood/*diagnosis
- Male
- Predictive Value of Tests
- MEDICINE
- MEDICIN
- Internal medicine
- Invärtesmedicin
- Gastroenterology
- Gastroenterologi
- Invärtesmedicin
- Internal Medicine
Added entries (persons, corporate bodies, meetings, titles ...)
- Nilsson, Torbjörn K.Örebro universitet,Hälsoakademin(Swepub:oru)tnnn (author)
- Björck, MUppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular surgery(Swepub:uu)mabjo425 (author)
- Acosta, StefanLund University,Lunds universitet,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular surgery,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)uro-sac (author)
- Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)
Related titles
- In:Scandinavian Journal of Clinical and Laboratory Investigation: Informa UK Limited68:3, s. 242-2480036-55131502-7686
Internet link
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17934974&dopt=Citation
- http://dx.doi.org/10.1080/00365510701646264FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3510
- https://doi.org/10.1080/00365510701646264
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16613
- https://lup.lub.lu.se/record/1139253
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