An oxygenated metabolite of benzo[a]pyrene increases hepatic beta-oxidation of fatty acids in chick embryos

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Westman, Ola,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Structor Miljöteknik AB, Örebro, Sweden,MTM (author)

An oxygenated metabolite of benzo[a]pyrene increases hepatic beta-oxidation of fatty acids in chick embryos

Article/chapterEnglish2014

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2014-01-03
Heidelberg :Springer Berlin/Heidelberg,2014
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LIBRIS-ID:oai:DiVA.org:oru-35205
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35205URI
https://doi.org/10.1007/s11356-013-2471-6DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding Agency:Swedish Knowledge Foundation (Stiftelsen for Kunskaps- och Kompetensutveckling)
Polycyclic aromatic hydrocarbons (PAHs) are well-known carcinogens to humans and ecotoxicological effects have been shown in several studies. However, PAHs can also be oxidized into more water soluble-oxygenated metabolites (Oxy-PAHs). The first purpose of the present project was to (1) assess the effects of a mixture containing three parent PAHs: anthracene, benz[a]anthracene, and benzo[a]pyrene versus a mixture of their oxygenated metabolites, namely: anthracene-9,10-dione, benz[a]anthracene-7,12-dione, and 9,10-dihydrobenzo[a]pyrene-7-(8H)-one on the hepatic fatty acid beta-oxidation in chicken embryos (Gallus gallus domesticus) exposed in ovo. The second and also main purpose of the project was to (2) assess the effects of the parent PAHs versus their oxy-PAHs analogues when injected individually, followed by (3) additional testing of the individual oxy-PAHs. The hepatic beta-oxidation was measured using a tritium release assay with [9,10-H-3]-palmitic acid (16:0) as substrate. The result from the first part (1) showed reduced hepatic beta-oxidation after exposure in ovo to a mixture of three PAHs, however, increased after exposure to the mixture of three oxy-PAHs compared to control. The result from the second part (2) and also the follow-up experiment (3) showed that 9,10-dihydrobenzo[a]pyrene-7-(8H)-one was the causative oxy-PAH. The implication of this finding on the risk assessment of PAH metabolite exposure in avian wildlife remains to be determined. To the best of our knowledge, no similar studies have been reported.

Subject headings and genre

NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
TEKNIK OCH TEKNOLOGIER Miljöbioteknik hsv//swe
ENGINEERING AND TECHNOLOGY Environmental Biotechnology hsv//eng
Polycyclic aromatic hydrocarbons
Oxygenated derivatives
Chick embryo
beta-oxidation
Biology
Biologi
Enviromental Science
Miljövetenskap

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Larsson, Maria,1975-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM(Swepub:oru)miln (author)
Venizelos, Nikolaos,1946-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)nvs (author)
Hollert, HennerInstitute for Environmental Research, Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany (author)
Engwall, Magnus,1965-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM(Swepub:oru)mel (author)
Örebro universitetInstitutionen för naturvetenskap och teknik (creator_code:org_t)

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In:Environmental Science and Pollution ResearchHeidelberg : Springer Berlin/Heidelberg21:9, s. 6243-62510944-13441614-7499

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