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Genetic variation i...
Genetic variation in the CYP2B6 Gene is related to circulating 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE-47) concentrations : an observational population-based study
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- Penell, Johanna (author)
- Uppsala universitet,Arbets- och miljömedicin
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Fall, Tove (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Axelsson, Tomas (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Lundmark, Per (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Morris, Andrew P. (author)
- Wellcome Trust Ctr Human Genet, Univ Oxford, Oxford, England
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- Lindgren, Cecilia (author)
- Wellcome Trust Ctr Human Genet, Univ Oxford, Oxford, England
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- Mahajan, Anubha (author)
- Wellcome Trust Ctr Human Genet, Univ Oxford, Oxford, England
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- Salihovic, Samira, 1985- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Lind, P Monica (author)
- Uppsala universitet,Arbets- och miljömedicin
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(creator_code:org_t)
- London : BioMed Central (BMC), 2014
- 2014
- English.
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In: Environmental Health. - London : BioMed Central (BMC). - 1476-069X. ; 13, s. 34-
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Since human CYP2B6 has been identified as the major CYP enzyme involved in the metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and that human 2B6 is a highly polymorphic CYP, with known functional variants, we evaluated if circulating concentrations of a major brominated flame retardant, BDE-47, were related to genetic variation in the CYP2B6 gene in a population sample.Methods: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (men and women all aged 70), 25 single nucleotide polymorphisms (SNPs) in the CYP2B6 gene were genotyped. Circulating concentrations of BDE-47 were analyzed by high-resolution gas chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS).Results: Several SNPs in the CYP2B6 gene were associated with circulating concentrations of BDE-47 (P = 10(- 4) to 10(-9)). The investigated SNPs came primarily from two haplotypes, although the correlation between the haplotypes was rather high. Conditional analyses adjusting for the SNP with the strongest association with the exposure (rs2014141) did not provide evidence for independent signals.Conclusion: Circulating concentrations of BDE-47 were related to genetic variation in the CYP2B6 gene in an elderly population.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- 2
- 2'
- 4
- 4'-tetrabromodiphenyl ether
- BDE-47
- CYP
- Elderly
- Epidemiology
- Gene
- SNP
- Chemistry
- Kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Penell, Johanna
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Lind, Lars
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Fall, Tove
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Syvänen, Ann-Chr ...
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Axelsson, Tomas
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Lundmark, Per
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show more...
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Morris, Andrew P ...
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Lindgren, Cecili ...
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Mahajan, Anubha
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Salihovic, Samir ...
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van Bavel, Bert, ...
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Ingelsson, Erik
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Lind, P Monica
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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Environmental He ...
- By the university
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Örebro University
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Uppsala University