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  • Elmarghani, Ahmed,1975-Örebro universitet,Institutionen för naturvetenskap och teknik (author)

Contribution of pharmaceuticals, fecal bacteria and endotoxin to the inflammatory responses to inland waters

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • Elsevier,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-35474
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35474URI
  • https://doi.org/10.1016/j.scitotenv.2014.04.090DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:City of ÖrebroKarlskoga Energi och Miljö ABMälarenergi ABPelagia Miljökonsult ABTyrens ABÖrebro University
  • The increasing contamination of freshwater with pharmaceuticals, surfactants, pesticides and other organic compounds are of major concern. As these contaminants are detected at trace levels in the environment it is important to determine if they elicit biological responses at the observed levels. In addition to chemical pollutants, there is also a concern for increasing levels of bacteria and other microorganisms in freshwater systems. In an earlier study, we observed the activation of inflammatory systems downstream of a wastewater treatment plant (WWTP) in southern Sweden. We also observed that the water contained unidentified components that were pro-inflammatory and potentiated the immune response in human urinary bladder epithelial cells. In order to determine if these effects were unique for the studied site or represent a common response in Swedish water, we have now performed a study on three WWTPs and their recipient waters in central Sweden. Analysis of immune responses in urinary bladder epithelial cells, monocyte-like cells and blood mononuclear cells confirm that these waters activate the immune system as well as induce pro-inflammatory responses. The results indicate that the cytokine profiles correlate to the endotoxin load of the waters rather than to the levels of pharmaceuticals or culturable bacteria load, suggesting that measurements of endotoxin levels and immune responses would be a valuable addition to the analysis of inland waters.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Pradhan, Ajay,1983-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)aypn (author)
  • Seyoum, AsmeromÖrebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)amsm (author)
  • Khalaf, Hazem,1981-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)hkf (author)
  • Ros, TorbjönPelagia Miljokonsult AB, Umeå, Sweden (author)
  • Forsberg, Lars-HåkanMälarenergi AB, Vasterås, Sweden (author)
  • Nermark, TomasKarlskoga Energi MO AB, Karlskoga, Sweden (author)
  • Osterman, LisaSkebäcks Reningsverk, Örebro, Sweden (author)
  • Wiklund, UlfTyrens AB, Umeå, Sweden (author)
  • Ivarsson, PerALS Scandinavia AB, Täby, Sweden (author)
  • Jass, Jana,1963-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)jjs (author)
  • Olsson, Per-Erik,1957-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)pkon (author)
  • Örebro universitetInstitutionen för naturvetenskap och teknik (creator_code:org_t)

Related titles

  • In:Science of the Total Environment: Elsevier488-489, s. 228-2350048-96971879-1026

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