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- Sun, Jielin (author)
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- 2008-08-31
- London :Nature Publishing Group,2008
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-3676
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3676URI
- https://doi.org/10.1038/ng.214DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-11348URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:117693438URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- Aged
- Chromosome Mapping
- Chromosomes; Human; Pair 17/*genetics
- Genetic Predisposition to Disease/*genetics
- Haplotypes/*genetics
- Hepatocyte Nuclear Factor 1-beta/*genetics
- Humans
- Linkage (Genetics)
- Male
- Middle Aged
- Polymorphism; Single Nucleotide/*genetics
- Prostatic Neoplasms/*genetics/pathology
- Risk Factors
- MEDICINE
- MEDICIN
- Clinical genetics
- Klinisk genetik
- Medical Genetics
- Medicinsk genetik
Added entries (persons, corporate bodies, meetings, titles ...)
- Zheng, Siqun Lilly (author)
- Wiklund, FredrikKarolinska Institutet (author)
- Isaacs, Sarah D. (author)
- Purcell, Lina D. (author)
- Gao, Zhengrong (author)
- Hsu, Fang-Chi (author)
- Kim, Seong-Tae (author)
- Liu, Wennuan (author)
- Zhu, Yi (author)
- Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003 (author)
- Adami, Hans-OlovKarolinska Institutet (author)
- Wiley, Kathleen E. (author)
- Dimitrov, Latchezar (author)
- Sun, Jishan (author)
- Li, Tao (author)
- Turner, Aubrey R. (author)
- Adams, Tamara S. (author)
- Adolfsson, JanKarolinska Institutet (author)
- Johansson, Jan-ErikÖrebro universitet,Hälsoakademin(Swepub:oru)jkjn (author)
- Lowey, James (author)
- Trock, Bruce J. (author)
- Partin, Alan W. (author)
- Walsh, Patrick C. (author)
- Trent, Jeffrey M. (author)
- Duggan, David (author)
- Carpten, John (author)
- Chang, Bao-Li (author)
- Grönberg, HenrikKarolinska Institutet (author)
- Isaacs, William B. (author)
- Xu, Jianfeng (author)
- Karolinska InstitutetUrologi och andrologi (creator_code:org_t)
Related titles
- In:Nature GeneticsLondon : Nature Publishing Group40:10, s. 1153-11551061-40361546-1718
Internet link
- https://doi.org/10.1038/ng.214Fulltext
- https://europepmc.org/articles/pmc3188432?pdf=render
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18758462&dopt=Citation
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-3676
- https://doi.org/10.1038/ng.214
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-11348
- http://kipublications.ki.se/Default.aspx?queryparsed=id:117693438
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- Wiklund, Fredrik
- Isaacs, Sarah D.
- Purcell, Lina D.
- Gao, Zhengrong
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- Hsu, Fang-Chi
- Kim, Seong-Tae
- Liu, Wennuan
- Zhu, Yi
- Stattin, Pär
- Adami, Hans-Olov
- Wiley, Kathleen ...
- Dimitrov, Latche ...
- Sun, Jishan
- Li, Tao
- Turner, Aubrey R ...
- Adams, Tamara S.
- Adolfsson, Jan
- Johansson, Jan-E ...
- Lowey, James
- Trock, Bruce J.
- Partin, Alan W.
- Walsh, Patrick C ...
- Trent, Jeffrey M ...
- Duggan, David
- Carpten, John
- Chang, Bao-Li
- Grönberg, Henrik
- Isaacs, William ...
- Xu, Jianfeng
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
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- Umeå University
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