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Ribavirin plasma co...
Ribavirin plasma concentration is a predictor of sustained virological response in patients treated for chronic hepatitis C virus genotype 2/3 infection
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- Pedersen, C. (author)
- Department of Infectious Diseases, University of Southern Denmark, Odense C, Denmark; Department of Infectious Diseases, Herlev Hospital, Copenhagen, Denmark
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- Alsiö, Åsa, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Lagging, Martin, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Langeland, N. (author)
- Department of Infectious Diseases, Haukeland University Hospital, Bergen, Norway; Institute of Medicine, University of Bergen, Bergen, Norway
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- Färkkilä, M. (author)
- Department of Gastroenterology, Helsinki University, Helsinki, Finland
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- Buhl, M. Rauning (author)
- Department of Infectious Diseases, Skejby Hospital, Aarhus University, Aarhus, Denmark
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- Mørch, K. (author)
- Department of Infectious Diseases, Haukeland University Hospital, Bergen, Norway; Institute of Medicine, University of Bergen, Bergen, Norway
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- Westin, Johan, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Sangfelt, P. (author)
- Uppsala universitet,Infektionssjukdomar
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- Norkrans, Gunnar, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Christensen, P. Brehm (author)
- Department of Infectious Diseases, University of Southern Denmark, Odense C, Denmark; Department of Infectious Diseases, Herlev Hospital, Copenhagen, Denmark
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(creator_code:org_t)
- 2010-04-01
- 2011
- English.
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In: Journal of Viral Hepatitis. - : Wiley. - 1352-0504 .- 1365-2893. ; 18:4, s. 245-51
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In hepatitis C virus (HCV) genotype 1 infection, the likelihood of obtaining sustained virological response (SVR) is associated with higher ribavirin exposure. Such an association has not been demonstrated for HCV genotype 2/3 infection, where a fixed 800 mg daily dosing of ribavirin is generally recommended. The primary aim of this study was to investigate the correlation between ribavirin concentration at day 29 and therapeutic response in patients with HCV genotype 2/3 infection. A total of 382 patients were randomized to 12 or 24 weeks of treatment with pegylated interferon-alfa 2a 180 μg weekly and 800 mg ribavirin daily. Trough plasma concentration of ribavirin was measured at day 29 and week 12 and the primary outcome was SVR (HCV-RNA undetectable 24 weeks after treatment). Of the 382 patients, 355 had a ribavirin concentration available at day 29. SVR was 84% among patients with a ribavirin concentration ≥2 mg/L at day 29 compared to 66% in those with concentrations <2 mg/L (P = 0.002). The corresponding figures in the 12-week treatment group were 74% and 57% (P = 0.12), and in the 24-week treatment group 91% and 75% (P = 0.02), respectively. In a multivariate analysis, ribavirin concentration at day 29 was an independent predictor of SVR (P = 0.002). In conclusion, a higher plasma ribavirin concentration is associated with an increased likelihood of achieving SVR in HCV genotype 2/3 infection. Individualization of ribavirin dosing may be helpful in improving outcome, especially in the presence of unfavourable baseline characteristics. This, however, requires evaluation in a prospective trial.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- drug concentration
- hepatitis C
- ribavirin
- treatment
- Infektionssjukdomar
- Infectious Diseases
- Invärtesmedicin
- Internal Medicine
- MEDICINE
- drug concentration; hepatitis C; ribavirin; treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pedersen, C.
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Alsiö, Åsa, 1965
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Lagging, Martin, ...
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Langeland, N.
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Färkkilä, M.
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Buhl, M. Rauning
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show more...
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Mørch, K.
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Westin, Johan, 1 ...
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Sangfelt, P.
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Norkrans, Gunnar ...
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Christensen, P. ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Journal of Viral ...
- By the university
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Örebro University
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Uppsala University
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University of Gothenburg