Transmission of hepatitis C virus by transfusion in Orebro County, Sweden, 1990-1992

A retrospective study of hepatitis C virus (HCV) transmission by transfusion was conducted in Orebro county. Out of the 7,900 active, registered blood donors, 21 repeatedly anti-HCV reactive (RIVA 2 positive or indeterminate) donors were diagnosed. Their 84 recipients from January 1990 through June 1992 were identified and 41 (49%) were alive in December 1992. A total of 13 anti-HCV reactive (RIBA 2 positive or indeterminate) were diagnosed in 39 investigated recipients. Of these 11 were previously undiagnosed, and seven were HCV RNA-positive. In the donor population 1.03% were anti-HCV-positive by ELISA, but only 0.09% were RIBA and HCV RNA-positive. In 1990, 0.06% of the blood components came from the HCV RNA-positive donors, and none during the first 6 months of 1992. In order to identify transfusion-transmitted HCV infections that took place before the introduction of tests for anti-HCV antibodies, patients with a history of transfusion and symptoms and signs of liver dysfunction or damage should be thoroughly tested.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
Adult; Aged; Blood Donors; Blood Transfusion; Female; Hepacivirus; Hepatitis C; Hepatitis C Antibodies; Human; Male; Middle Age; Retrospective Studies; RNA
Viral; Support
Non-U.S. Gov't; Sweden
Infektionssjukdomar
Infectious Diseases

Duberg, Ann-Sofi,1957-Departments of Infectious Diseases, Örebro Medical Center Hospital, Örebro, Sweden(Swepub:oru)adg (author)
Sönnerborg, AndersDepartments of Clinical Microbiology and Immunology, Örebro Medical Center Hospital, Örebro, Sweden (author)
Olcén, PerDepartments of Division of Clinical Virology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden (author)
Karolinska InstitutetDepartments of Infectious Diseases, Örebro Medical Center Hospital, Örebro, Sweden (creator_code:org_t)

In:Scandinavian Journal of Infectious Diseases: Informa UK Limited27:5, s. 449-4520036-55481651-1980

By the author/editor: Norda, Rut; Duberg, Ann-Sofi ...; Sönnerborg, Ande ...; Olcén, Per

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

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