Coeliac disease and risk of sarcoidosis

BACKGROUND AND AIM: Several case reports indicate a link between coeliac disease (CD) and sarcoidosis. Our main objective was to investigate the risk of subsequent sarcoidosis in individuals with CD in a general population cohort study. A second aim was to estimate the risk of CD in individuals with prior sarcoidosis.METHODS: We used Cox proportional hazards method to calculate the risk of subsequent sarcoidosis in 14,349 individuals who had received a diagnosis of CD (1964-2003) and 69,998 age- and sex-matched individuals without a diagnosis of CD. Subjects were identified through the Swedish national Inpatient Register. Conditional logistic regression was used to study the risk of CD associated with prior sarcoidosis.RESULTS: CD was associated with an increased risk of sarcoidosis (Hazard ratio (HR) = 4.03; 95% CI = 2.32-7.00; p < 0.001), and was not notably affected by adjustment for socioeconomic index. In individuals with CD listed as the main diagnosis, the HR was 3.66 (95% CI HR = 1.80-7.45; p < 0.001). Prior sarcoidosis was associated with an increased risk of CD (Odds ratio = 3.58; 95% CI = 1.98-6.45; p < 0.001).CONCLUSION: Immune characteristics of CD may be linked to an increased risk of sarcoidosis.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Adolescent
Adult
Aged
Aged; 80 and over
Celiac Disease/complications/*epidemiology
Child
Child; Preschool
Cohort Studies
Female
Humans
Infant
Infant; Newborn
Male
Middle Aged
Proportional Hazards Models
Registries
Risk Factors
Sarcoidosis/complications/*epidemiology
Sweden/epidemiology
MEDICINE
MEDICIN
Cardiology
Kardiologi
Epidemiology
Epidemiologi
Epidemiologi
Epidemiology

Wahlstrom, JanKarolinska Institutet (author)
Grunewald, JohanKarolinska Institutet (author)
Ekbom, AndersKarolinska Institutet (author)
Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Hälsoakademin(Swepub:oru)smy (author)
Karolinska InstitutetHälsoakademin (creator_code:org_t)

In:Sarcoidosis Vasculitis and Diffuse Lung DiseasesCormano : Casa Editrice Mattioli24:2, s. 121-1261124-0490
In:OrderCormano : Casa Editrice Mattioli24:2, s. 121-1260167-80941572-9273

By the author/editor: Ludvigsson, Jona ...; Wahlstrom, Jan; Grunewald, Johan; Ekbom, Anders; Montgomery, Scot ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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