Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis

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Günaltay, Sezin,1986-Örebro universitet,Institutionen för hälsovetenskap och medicin (author)

Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis

Article/chapterEnglish2014

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WJG Press,2014
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LIBRIS-ID:oai:DiVA.org:oru-37676
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37676URI
https://doi.org/10.3748/wjg.v20.i34.12249DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies:Research Committee of Örebro County CouncilÖrebro University
AIM: To investigate Toll-like receptor (TLR) signaling regulators in microscopic and ulcerative colitis patients.METHODS: Total RNA and microRNA were isolated from fresh frozen colonic biopsies of non-inflamed controls and patients with active or in-remission collagenous colitis (CC), lymphocytic colitis (LC), or ulcerative colitis (UC). We compared expressions of interleukin-1 receptor-associated kinase (IRAK)-2, IRAK-M, interleukin (IL)-37, microRNA (miR)-146a, miR-155, and miR-21 using quantitative real time reverse transcription polymerase chain reaction.RESULTS: IRAK-M expression was increased in LC patients with active disease in histopathological remission (LC-HR; P = 0.02) and UC patients (P = 0.01), but no differences in IRAK-2 expression were detected compared to controls. miR-146a, -155 and -21 expressions were increased in LC-HR (P = 0.04, 0.07, and 0.004) and UC (P = 0.02, 0.04 and 0.03) patients. miR-146a and miR-21 expressions were significantly enhanced in UC patients compared to UC remission (UC-R; P = 0.01 and 0.04). Likewise, active CC patients showed significantly increased expression of miR-155 (P = 0.003) and miR-21 (P = 0.006). IL-37 expression was decreased in both CC (P = 0.03) and LC (P = 0.04) patients with a similar trend in UC patients but not statistically significant, whilst it was increased in UC-R patients compared to controls (P = 0.02) and active UC (P = 0.001).CONCLUSION: The identification of differentially expressed miRNAs, IL-37, and IRAK-M suggests different pathophysiologic mechanisms in various disease stages in LC, CC, and UC. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Interleukin-37
MicroRNA
Lymphocytic colitis
Collagenous colitis
Ulcerative colitis

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Nyhlin, Nils,1971-Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)nnn (author)
Kumawat, Ashok Kumar,1982-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)akt (author)
Tysk, Curt,1949-Region Örebro län,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)ctk (author)
Bohr, Johan,1957-Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jbr (author)
Hultgren, Olof,1970-Örebro universitet,Institutionen för läkarutbildning,Region Örebro län,Department of Microbiology and Immunology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)ovhn (author)
Hultgren-Hörnquist, Elisabeth,1965-Örebro universitet,Institutionen för läkarutbildning(Swepub:oru)eht (author)
Örebro universitetInstitutionen för hälsovetenskap och medicin (creator_code:org_t)

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In:World Journal of Gastroenterology: WJG Press20:34, s. 12249-122591007-93272219-2840

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