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CRIM1 is expressed ...
CRIM1 is expressed at higher levels in drug-resistant than in drug-sensitive myeloid leukemia HL60 cells
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- Prenkert, Malin, 1967- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Clinical Research Center, Örebro University Hospital, Örebro; Sweden
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- Uggla, Bertil, 1962- (author)
- Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Tidefelt, Ulf, 1951- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Strid, Hilja, 1962- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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(creator_code:org_t)
- Athens, Greece : International Institute of Anticancer Research, 2010
- 2010
- English.
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In: Anticancer Research. - Athens, Greece : International Institute of Anticancer Research. - 0250-7005 .- 1791-7530. ; 30:10, s. 4157-61
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Abstract
Subject headings
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- Aim: The aim of this study was to explore possible differences in the mRNA expression levels of CRIM1, SMAD5, BMP4 and BMP7 in sensitive (S) and multidrug-resistant (R0.5) myeloid leukemia HL60 cells.Materials and Methods: HL60S and HL60R0.5 cells were exposed to daunorubicin (DNR) or cytarabine (Ara-C).Results: Baseline levels of CRIM1 were found to be 15-fold higher in HL60R0.5 than in HL60S. Sixteen hours of exposure to DNR resulted in a 5.6-fold increase in CRIM1 levels in HL60S. Exposure to either DNR or Ara-C resulted in modest increases in CRIM1 levels in HL60R0.5. Similarly, baseline levels of SMAD5 and BMP4 were higher in HL60R0.5 than in HL60S cells. Analysis of the drug SMAD5-resistance marker permeability-glycoprotein (Pgp) revealed that CRIM1 and Pgp exhibit a covariance pattern of expression.Conclusion: This study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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