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Failure matters :
Failure matters : unsuccessful cytogenetics and unperformed cytogenetics are associated with a poor prognosis in a population-based series of acute myeloid leukaemia
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- Lazarevic, Vladimir (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden; Lund University, Sweden
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- Hörstedt, Ann-sofi (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden
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- Johansson, Bertil (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,University of and Regional Labs Regional Skåne, Sweden; Lund University, Sweden
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- Antunovic, Petar (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Region Östergötland, Hematologiska kliniken US
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- Billström, Rolf (author)
- , SwedenDepartment of Medicine, Central Hospital Skövde, Sweden
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- Derolf, Asa (author)
- Karolinska Institutet
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- Lehmann, Sören (author)
- Karolinska Institutet,Uppsala universitet,Hematologi,Karolinska University Hospital, Sweden; Karolinska University Hospital, Sweden
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- Möllgård, Lars (author)
- Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Peterson, Stefan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden
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- Stockelberg, Dick (author)
- Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Uggla, Bertil, 1962- (author)
- Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Vennström, Lovisa (author)
- Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Wahlin, Anders (author)
- Umeå universitet,Onkologi,Umeå University, Sweden
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi,Academic Hospital, Sweden
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden; Lund University, Sweden; Academic Hospital, Sweden
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(creator_code:org_t)
- 2014-10-03
- 2015
- English.
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In: European Journal of Haematology. - Hoboken, USA : Wiley-Blackwell. - 0902-4441 .- 1600-0609. ; 94:5, s. 419-423
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Unsuccessful cytogenetics (UC) in patients with acute myeloid leukaemia (AML) treated on different SWOG trials was recently reported to be associated with increased age and dismal outcome. To ascertain whether this holds true also in unselected patients with AML, we retrieved all cytogenetic reports in cases from the population-based Swedish AML Registry. Between 1997 and 2006, 1737 patients below 80 yr of age without myelosarcoma or acute promyelocytic leukaemia received intensive treatment. The frequencies of UC and unperformed cytogenetics (UPC) were 2.1% and 20%, respectively. The early death rates differed between the cytogenetic subgroups (P = 0.006) with the highest rates in patients with UC (14%) and UPC (12%) followed by high-risk (HR) AML, intermediate risk (IR) and standard risk (SR) cases successfully karyotyped (8.6%, 5.9%, and 5.8%, respectively). The complete remission rate was lower in UC and UPC and HR compared with the other risk groups (P < 0.001). The overall five-year survival rates were 25% for UC and 22% for UPC, whereas the corresponding frequencies for SR, IR and HR AML patients without UC and UPC were 64%, 31% and 15%, respectively. In conclusion, lack of cytogenetic data translates into a poor prognosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- unsuccessful metaphase analysis; Unperformed cytogenetics
- acute myeloid leukaemia
- karyotype
- survival
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lazarevic, Vladi ...
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Hörstedt, Ann-so ...
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Johansson, Berti ...
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Antunovic, Petar
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Billström, Rolf
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Derolf, Asa
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Lehmann, Sören
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Möllgård, Lars
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Peterson, Stefan
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Stockelberg, Dic ...
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Uggla, Bertil, 1 ...
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Vennström, Lovis ...
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Wahlin, Anders
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Höglund, Martin
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Juliusson, Gunna ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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European Journal ...
- By the university
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Örebro University
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Umeå University
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Lund University
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Uppsala University
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Linköping University
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Karolinska Institutet