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  • Lazarevic, VladimirLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden; Lund University, Sweden (author)

Failure matters : unsuccessful cytogenetics and unperformed cytogenetics are associated with a poor prognosis in a population-based series of acute myeloid leukaemia

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2014-10-03
  • Hoboken, USA :Wiley-Blackwell,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-37791
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37791URI
  • https://doi.org/10.1111/ejh.12446DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103131URI
  • https://lup.lub.lu.se/record/4692049URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239856URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-117785URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:131073691URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Cancer Society; Swedish Research Council; Regional Cancer Centers; Swedish Association of Local Authorities and Regions (SKL)
  • Unsuccessful cytogenetics (UC) in patients with acute myeloid leukaemia (AML) treated on different SWOG trials was recently reported to be associated with increased age and dismal outcome. To ascertain whether this holds true also in unselected patients with AML, we retrieved all cytogenetic reports in cases from the population-based Swedish AML Registry. Between 1997 and 2006, 1737 patients below 80 yr of age without myelosarcoma or acute promyelocytic leukaemia received intensive treatment. The frequencies of UC and unperformed cytogenetics (UPC) were 2.1% and 20%, respectively. The early death rates differed between the cytogenetic subgroups (P = 0.006) with the highest rates in patients with UC (14%) and UPC (12%) followed by high-risk (HR) AML, intermediate risk (IR) and standard risk (SR) cases successfully karyotyped (8.6%, 5.9%, and 5.8%, respectively). The complete remission rate was lower in UC and UPC and HR compared with the other risk groups (P < 0.001). The overall five-year survival rates were 25% for UC and 22% for UPC, whereas the corresponding frequencies for SR, IR and HR AML patients without UC and UPC were 64%, 31% and 15%, respectively. In conclusion, lack of cytogenetic data translates into a poor prognosis.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hörstedt, Ann-sofiLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden(Swepub:lu)med-afh (author)
  • Johansson, BertilLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,University of and Regional Labs Regional Skåne, Sweden; Lund University, Sweden(Swepub:lu)kgen-bjo (author)
  • Antunovic, PetarLinköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Region Östergötland, Hematologiska kliniken US(Swepub:liu)petan27 (author)
  • Billström, Rolf, SwedenDepartment of Medicine, Central Hospital Skövde, Sweden (author)
  • Derolf, AsaKarolinska Institutet (author)
  • Lehmann, SörenKarolinska Institutet,Uppsala universitet,Hematologi,Karolinska University Hospital, Sweden; Karolinska University Hospital, Sweden(Swepub:uu)sorle534 (author)
  • Möllgård, LarsDepartment of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Peterson, StefanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden(Swepub:lu)med-sfp (author)
  • Stockelberg, DickDepartment of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Uggla, Bertil,1962-Department of Medicine, Örebro University Hospital, Örebro, Sweden(Swepub:oru)bua (author)
  • Vennström, LovisaDepartment of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Wahlin, AndersUmeå universitet,Onkologi,Umeå University, Sweden(Swepub:umu)anwa0027 (author)
  • Höglund, MartinUppsala universitet,Hematologi,Academic Hospital, Sweden(Swepub:uu)martinhl (author)
  • Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden; Lund University, Sweden; Academic Hospital, Sweden(Swepub:lu)stem-gju (author)
  • Stamcellscentrum (SCC)Avdelningen för stamcellsforskning (creator_code:org_t)

Related titles

  • In:European Journal of HaematologyHoboken, USA : Wiley-Blackwell94:5, s. 419-4230902-44411600-0609

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