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Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

Wadelius, Mia (author)
Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
Marshall, S. E. (author)
Medical Research Institute, College of Medicine, Dentistry and Nursing, Ninewells Hospital, University of Dundee, Dundee, UK
Islander, Gunilla (author)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Nordang, Leif (author)
Uppsala universitet,Öron-, näs- och halssjukdomar
Karawajczyk, Malgorzata (author)
Uppsala universitet,Biokemisk struktur och funktion
Yue, Q-Y (author)
Medical Products Agency, Uppsala, Sweden
Terreehorst, I. (author)
Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
Baranova, E. V. (author)
Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands
Hugosson, Svante, 1956- (author)
Örebro universitet,Institutionen för läkarutbildning,Region Örebro län,Department of Otorhinolaryngology, Örebro University Hospital, Örebro, Sweden
Sköldefors, K. (author)
Department of Otorhinolaryngology, Hudiksvall Hospital, Hudiksvall, Sweden
Pirmohamed, M. (author)
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
Maitland-van der Zee, A-H (author)
Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands
Alfirevic, A. (author)
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
Hallberg, Pär (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk farmakogenomik och osteoporos
Palmer, C. N. A. (author)
Medical Research Institute, College of Medicine, Dentistry and Nursing, University of Dundee, Dundee, UK
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 (creator_code:org_t)
2014-06-24
2014
English.
In: Clinical Pharmacology and Therapeutics. - : Nature Publishing Group. - 0009-9236 .- 1532-6535. ; 96:4, s. 477-481
  • Research review (peer-reviewed)
Abstract Subject headings
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  • Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Keyword

Pharmaceutical Pharmacology
Farmaceutisk farmakologi

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