Electrochemotherapy - possible benefits and limitations to its use in the head and neck region

Landström, Fredrik,1966-Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University Hospital, Örebro, Sweden (author)

Funding agency: Genetronics Inc., San Diego, CA, USA
Conclusion: Electrochemotherapy (ECT) is an efficacious treatment. It should, however, be used with some caution in the treatment of head and neck cancer.Objectives: To assess local tumor control, safety, survival, and functional outcome after treatment of cancer in the head and neck region with ECT.Methods: Four patients with primary T2 cancer of the oral cavity or oropharynx and one patient with a metastasis of renal cancer in the masseter muscle were treated with ECT with intratumorally administered bleomycin. Control biopsies were carried out 2 months after treatment. Postoperative radiotherapy was performed based on tumor T-stage and the depth of tumor infiltration. Serious adverse events and treatment malfunctions were recorded. The follow-up time was 24 months for the surviving patients and 20 months overall. The PSS-HN scale was used to assess the functional outcome.Results: No local recurrence was recorded in any patient during the follow-up. However, only one patient was treated with ECT alone. There were four serious adverse events: one nearly lethal bleeding, two cases of osteoradionecrosis, and a fistula. One patient died from distant metastasis. The other patients were tumor-free both locally and overall at 24 months. The median functional outcome in all parameters was worse 1 year after treatment.

Reizenstein, JohanÖrebro University Hospital, Örebro, Sweden (author)
Nilsson, ChristerÖrebro University Hospital, Örebro, Sweden (author)
von Beckerath, Mathias,1966-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)msvt (author)
Löfgren, Lennart,1939-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)ltln (author)
Adamsson, Gun-BrittÖrebro University Hospital, Örebro, Sweden (author)
Möller, Claes,1950-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)cmr (author)
Örebro universitetInstitutionen för hälsovetenskap och medicin (creator_code:org_t)

By the author/editor: Landström, Fredr ...; Reizenstein, Joh ...; Nilsson, Christe ...; von Beckerath, M ...; Löfgren, Lennart ...; Adamsson, Gun-Br ...; show more...; Möller, Claes, 1 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Otorhinolaryngol ...

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