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DanTox-a novel join...
DanTox-a novel joint research project using zebrafish (Danio rerio) to identify specific toxicity and molecular modes of action of sediment-bound pollutants
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- Keiter, Steffen, 1971- (author)
- Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany,MTM
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- Peddinghaus, Sabrina (author)
- Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany
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- Feiler, Ute (author)
- German Federal Institute for Hydrology (BfG), Koblenz, Germany
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- von der Goltz, Britta (author)
- Aquatic Ecology and Toxicology Group, Department of Zoology, University of Heidelberg, Heidelberg, Germany
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- Hafner, Christoph (author)
- Hydrotox GmbH, Freiburg, Germany
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- Ho, Nga Yu (author)
- Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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- Rastegar, Sepand (author)
- Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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- Otte, Jens (author)
- Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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- Ottermanns, Richard (author)
- Research Institute GAIAC, Aachen, Germany
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- Reifferscheid, Georg (author)
- German Federal Institute for Hydrology (BfG), Koblenz, Germany
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- Strähle, Uwe (author)
- Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics (ITG), Eggenstein-Leopoldshafen, Germany
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- Braunbeck, Thomas (author)
- Aquatic Ecology and Toxicology Group, Department of Zoology, University of Heidelberg, Heidelberg, Germany
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- Hammers-Wirtz, Monika (author)
- Research Institute GAIAC, Aachen, Germany
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- Hollert, Henner (author)
- Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany
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(creator_code:org_t)
- 2010-04-14
- 2010
- English.
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In: Journal of Soils and Sediments. - Heidelberg, Germany : Springer. - 1439-0108 .- 1614-7480. ; 10:4, s. 714-717
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: The European Water Framework Directive aimsto achieve a good ecological and chemical status in surface water of European rivers by the year 2015. Since sediments and particulate matter act as secondary sources for pollutants, applied sediment toxicology is perceived to play a major rolefor obtaining new knowledge that can contribute to successful attainment of the goal. However, the existing bioassays for sediment toxicity analyses do not provide sufficient data concerning bioavailability of environmental pollutants. In this regard, there is an urgent need to combine sediment contact assays with gene expression analysis to investigate mechanism-specific sediment toxicity.Purpose: The aim of the novel joint research project is todevelop a eukaryotic test system, which can be used to investigate the ecotoxicological effects of contaminated sediments on gene expression level (DNA-array and RT-PCR).Current ecotoxicological research customarily involves a battery of bioassays to cover different toxicological endpoints (e.g., teratogenicity, genotoxicity, mutagenicity, Ah-receptor mediated toxicity, neurotoxicity). In contrast, methods that detect alterations in gene expression offer deeper insight by elucidating how chemical exposure and/or environmental challenge affect multiple metabolic pathways leading to these particular kinds of toxic response. Gene expression profiles reflect the way cells and organisms adapt or respond to a changing environment.Conclusion: The present project aspires to increase the fundamental molecular and physiological knowledge concerning the mode of action of environmental toxicants in zebrafish (Danio rerio). By working with partners from the academic and research institutions as well as from industry and waterway regulations, the success of this basic research-driven joint project in terms of development and implementation of novel sediment toxicity methods will be realized.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- Danio rerio
- Genomics
- Sediments
- Toxicity
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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Keiter, Steffen, ...
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Peddinghaus, Sab ...
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Feiler, Ute
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von der Goltz, B ...
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Hafner, Christop ...
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Ho, Nga Yu
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Rastegar, Sepand
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Otte, Jens
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Ottermanns, Rich ...
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Reifferscheid, G ...
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Strähle, Uwe
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Braunbeck, Thoma ...
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Hammers-Wirtz, M ...
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Hollert, Henner
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
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Journal of Soils ...
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Örebro University