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Investigating assoc...
Investigating associations between milk metabolite profiles and milk traits of Holstein cows
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- Melzer, Nina (author)
- Research Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
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- Wittenburg, Dörte (author)
- Research Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
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- Hartwig, S (author)
- Landeskontrollverband für Leistungs-und Qualitatsprufung Mecklenburg-Vorpommern e.V. (LKV), Güstrow, Germany
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- Jakubowski, S (author)
- Landeskontrollverband für Leistungs-und Qualitatsprufung Mecklenburg-Vorpommern e.V. (LKV), Güstrow, Germany
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- Kesting, U (author)
- Landeskontrollverband für Leistungs-und Qualitatsprufung Mecklenburg-Vorpommern e.V. (LKV), Güstrow, Germany
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- Willmitzer, Lothar (author)
- Max Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany
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- Lisec, Jan (author)
- Max Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany
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- Reinsch, Norbert (author)
- Research Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
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- Repsilber, Dirk, 1971- (author)
- Research Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
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Research Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany Landeskontrollverband für Leistungs-und Qualitatsprufung Mecklenburg-Vorpommern eV. (LKV), Güstrow, Germany (creator_code:org_t)
- New York, USA : Elsevier, 2013
- 2013
- English.
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In: Journal of Dairy Science. - New York, USA : Elsevier. - 0022-0302 .- 1525-3198. ; 96:3, s. 1521-34
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- In the field of dairy cattle research, it is of great interest to improve the detection and prevention of diseases (e.g., mastitis and ketosis) and monitor specific traits related to the state of health and management. During the standard milk performance test, traditional milk traits are monitored, and quality and quantity are screened. In addition to the standard test, it is also now possible to analyze milk metabolites in a high-throughput manner and to consider them in connection with milk traits to identify functionally important metabolites that can also serve as biomarker candidates. We present a study in which 190 milk metabolites and 14 milk traits of 1,305 Holstein cows on 18 commercial farms were investigated to characterize interrelations of milk metabolites between each other, to milk traits from the milk standard performance test, and to influencing factors such as farm and sire effect (half-sib structure). The effect of influencing factors (e.g., farm) varied among metabolites and traditional milk traits. The investigations of associations between metabolites and milk traits revealed groups of metabolites that show, for example, positive correlations to protein and casein, and negative correlations to lactose and pH. On the other hand, groups of metabolites jointly associated with the investigated milk traits can be identified and functionally discussed. To enable a multivariate investigation, 2 machine learning methods were applied to detect important metabolites that are highly correlated with the investigated traditional milk traits. For somatic cell score, uracil, lactic acid, and 9 other important metabolites were detected. Lactic acid has already been proposed as a biomarker candidate for mastitis in the recent literature. In conclusion, we found sets of metabolites eligible to predict milk traits, enabling the analysis of milk traits from a metabolic perspective and discussion of the possible functional background for some of the detected associations.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- metabolite profile
- milk trait
- biomarker candidate
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Melzer, Nina
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Wittenburg, Dört ...
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Hartwig, S
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Jakubowski, S
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Kesting, U
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Willmitzer, Loth ...
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show more...
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Lisec, Jan
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Reinsch, Norbert
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Repsilber, Dirk, ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
- Articles in the publication
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Journal of Dairy ...
- By the university
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Örebro University