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Thrombin-induced pl...
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Boknäs, NiklasLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
(author)
Thrombin-induced platelet activation via PAR4 : pivotal role for exosite II
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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Stuttgart, Germany :Schattauer Gmbh,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-41366
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-41366URI
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https://doi.org/10.1160/TH13-12-1013DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111269URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council [K2010-65X-15060-07-3, K2013-65X-15060-10-3]; Swedish Heart and Lung Foundation [20100219, 20120263]
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Thrombin-induced platelet activation via PAR1 and PAR4 is an important event in haemostasis. Although the underlying mechanisms responsible for ensuring efficient PAR1 activation by thrombin have been extensively studied, the potential involvement of recognitions sites outside the active site of the protease in thrombin-induced PAR4 activation is largely unknown. In this study, we developed a new assay to assess the importance of exosite I and II for PAR4 activation with alpha- and gamma-thrombin. Surprisingly, we found that exosite II is critical for activation of PAR4. We also show that this dependency on exosite II likely represents a new mechanism, as it is unaffected by blockage of the previously known interaction between thrombin and glycoprotein Ib alpha.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Faxälv, LarsÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Klinisk kemi(Swepub:liu)larfa71
(author)
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Sanchez Centellas, DanielLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)dansa59
(author)
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Wallstedt, MariaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)marwa83
(author)
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Ramström, Sofia,1973-Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)sofra86
(author)
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Grenegård, Magnus,1963-Örebro universitet,Institutionen för hälsovetenskap och medicin,Cardiovascular Research Center,University of Örebro, Sweden(Swepub:liu)maggr06
(author)
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Lindahl, TomasÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Klinisk kemi(Swepub:liu)tomli13
(author)
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Linköpings universitetAvdelningen för mikrobiologi och molekylär medicin
(creator_code:org_t)
Related titles
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In:Thrombosis and HaemostasisStuttgart, Germany : Schattauer Gmbh112:3, s. 558-5650340-62452567-689X
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