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Wwox expression may...
Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients
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- Göthlin Eremo, Anna, 1980- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,University of Örebro, Sweden
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- Wegman, Pia, 1964- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,University of Örebro, Sweden
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- Stål, Olle (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US
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- Nordenskjöld, Bo (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US
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- Fornander, Tommy (author)
- Karolinska Institutet,Stockholm South Gen Hospital, Sweden
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- Wingren, Sten, 1950- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,University of Örebro, Sweden
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(creator_code:org_t)
- 2013-01-31
- 2013
- English.
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In: Oncology Reports. - Athens, Greece : Spandidos Publications. - 1021-335X .- 1791-2431. ; 29:4, s. 1467-1474
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Abstract
Subject headings
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- Reduced or absent Wwox expression has recently been associated with tamoxifen resistance in breast cancer and has also been proposed as a candidate predictive marker for treatment. We aimed to investigate the correlation of Wwox expression with the outcome of tamoxifen treatment by examining tissues from 912 randomized breast cancer patients. Paraffin-embedded tissues from patient tumors were arranged on tissue microarray, and Wwox protein was stained using immunohistochemistry. After microscopic examination, the results were analyzed with Cox regression, Kaplan-Meier survival curves and the log-rank test. In the group of cases having a tumor absent for Wwox expression, there was no difference in recurrence-free survival between treated and untreated patients (P=0.81). For treated cases with a tumor expressing moderate or strong Wwox protein, recurrence-free survival was improved (P=0.001 and P=0.003, respectively). The test for interaction between Wwox and treatment response demonstrated a decreased risk of recurrence for treated patients with a moderate or strong Wwox expression (HR=0.31, 95% CI 0.10-0.98 and HR=0.28, 95% CI 0.08-0.97, respectively). Our results indicate that patients with high expression of Wwox may gain more benefit from treatment with tamoxifen.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Wwox
- breast cancer
- tamoxifen
- randomized patients
- Biomedicin
- Biomedicine
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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