Search: onr:"swepub:oai:DiVA.org:oru-44342" >
Satisfactory outcom...
Satisfactory outcome after intensive chemotherapy with pragmatic use of minimal residual disease (MRD) monitoring in older patients with Philadelphia-negative B cell precursor acute lymphoblastic leukaemia : a Swedish registry-based study
-
- Bergfelt, Emma (author)
- Uppsala universitet,Hematologi
-
- Kozlowski, Piotr, 1969- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,University of Örebro, Sweden
-
- Ahlberg, Lucia (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för kliniska vetenskaper,Region Östergötland, Hematologiska kliniken US
-
show more...
-
- Hulegårdh, Erik (author)
- Department of Haematology and Coagulation, Sahlgrenska University Hospital, Göteborg, Sweden
-
- Hagglund, Hans (author)
- Uppsala universitet,Karolinska Institutet,Hematologi
-
- Karlsson, Karin (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden
-
- Markuszewska-Kuczymska, Alicja (author)
- Department of Haematology, Cancer Center, University Hospital of Umeå, Umeå , Sweden
-
- Tomaszewska-Toporska, Beata (author)
- Department of Haematology, Skåne University Hospital, Lund, Sweden
-
- Smedmyr, Bengt (author)
- Uppsala universitet,Hematologi
-
- Åström, Maria, 1959- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,University of Örebro, Sweden
-
- Amini, Rose-Marie (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Hallböök, Hélene (author)
- Uppsala universitet,Hematologi
-
show less...
-
(creator_code:org_t)
- 2015-03-22
- 2015
- English.
-
In: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 32:4
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- The introduction of minimal residual disease (MRD) monitoring, in the Swedish national guidelines for acute lymphoblastic leukaemia, was evaluated in 35 patients aged 46-79 years (median 61), who were diagnosed from 2007 to 2011 and treated with high-intensity, block-based chemotherapy (ABCDV/VABA induction). Both a high complete remission rate (91 %) and acceptable overall survival (OS) rate (47 %) at 5 years were achieved. MRD by flow cytometry was measured in 73 % of the patients reaching complete remission after the first course, but was omitted by the clinicians for eight patients who were either over 70 years of age or already met conventional high-risk criteria. Factors negatively influencing OS were age over 65 years and WHO status >= 2. MRD < 0.1 % after induction had positive impact on continuous complete remission but not on OS. Only five patients were allocated to allogeneic haematopoietic stem cell transplantation in first remission, mainly due to conventional high risk factors. Thus, use of intensive remission induction therapy is effective in a selection of older patients. In a population for whom the possibilities of treatment escalation are limited, the optimal role of MRD monitoring remains to be determined.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Acute lymphoblastic leukaemia
- Adults
- Minimal residual disease
- Flow cytometry
- Onkologi
- Oncology
- Acute lymphoblastic leukaemia
- Adults
- Minimal residual disease
- Flow
- cytometry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bergfelt, Emma
-
Kozlowski, Piotr ...
-
Ahlberg, Lucia
-
Hulegårdh, Erik
-
Hagglund, Hans
-
Karlsson, Karin
-
show more...
-
Markuszewska-Kuc ...
-
Tomaszewska-Topo ...
-
Smedmyr, Bengt
-
Åström, Maria, 1 ...
-
Amini, Rose-Mari ...
-
Hallböök, Hélene
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Medical Oncology
- By the university
-
Örebro University
-
Lund University
-
Linköping University
-
Karolinska Institutet
-
Uppsala University