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Differential accumu...
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Gao, YanState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
(author)
Differential accumulation and elimination behavior of perfluoroalkyl acid isomers in occupational workers in a manufactory in China
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-05-13
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American Chemical Society (ACS),2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-45298
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-45298URI
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https://doi.org/10.1021/acs.est.5b00778DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-193757URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:National Basic Research Program of China 2015CB453100National Natural Science Foundation of China 21477154 21321004Strategic Priority Research Program of the Chinese Academy of Science XDB14010400 YSW2013A01RCEES RCEES-QN-20130047F
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In this study, serum and urine samples were collected from 36 occupational workers in a fluorochemical manufacturing plant in China from 2008 to 2012 to evaluate the body burden and possible elimination of linear and branched perfluoroalkyl acids (PFAAs). Indoor dust, total suspended particles (TSP), diet, and drinking water samples were also collected to trace the occupational exposure pathway to PFAA isomers. The geometric mean concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS) isomers in the serum were 1386, 371, and 863 ng mL(-1), respectively. The linear isomer of PFOS, PFOA, and PFHxS was the most predominant PFAA in the serum, with mean proportions of 63.3, 91.1, and 92.7% respectively, which were higher than the proportions in urine. The most important exposure routes to PFAA isomers in the occupational workers were considered to be the intake of indoor dust and TSP. A renal clearance estimation indicated that branched PFAA isomers had a higher renal clearance rate than did the corresponding linear isomers. Molecular docking modeling implied that linear PFOS (n-PFOS) had a stronger interaction with human serum albumin (HSA) than branched isomers did, which could decrease the proportion of n-PFOS in the blood of humans via the transport of HSA.
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Fu, JianjieState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
(author)
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Cao, HuimingState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
(author)
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Wang, YaweiState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; Institute of Environment and Health, Ministry of Education, Jianghan University, Wuhan, China
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Zhang, AiqianState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
(author)
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Liang, YongInstitute of Environment and Health, Ministry of Education, Jianghan University, Wuhan, China; School of Medicine, Ministry of Education, Jianghan University, Wuhan, China; Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, Jianghan University, Wuhan, China
(author)
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Wang, Thanh,1979-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Center,Örebro universitet, Institutionen för naturvetenskap och teknik(Swepub:liu)thawa68
(author)
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Zhao, ChunyanSchool of Pharmacy, Lanzhou University, Lanzhou, China
(author)
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Jiang, GuibinState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
(author)
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State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; Institute of Environment and Health, Ministry of Education, Jianghan University, Wuhan, China
(creator_code:org_t)
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In:Environmental Science and Technology: American Chemical Society (ACS)49:11, s. 6953-69620013-936X1520-5851
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Gao, Yan
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Fu, Jianjie
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Cao, Huiming
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Wang, Yawei
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Zhang, Aiqian
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Liang, Yong
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