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Atmospheric-Pressure Chemical Ionization Tandem Mass Spectrometry (APGC/MS/MS) an Alternative to High-Resolution Mass Spectrometry (HRGC/HRMS) for the Determination of Dioxins
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Geng, Dawei, 1986- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Cherta, Laura (author)
- Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain
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- Nacher-Mestre, Jaime (author)
- Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain
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- Portoles, Tania (author)
- Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain
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- Abalos, Manuela (author)
- Laboratory of Dioxins, Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain
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- Saulo, Jordi (author)
- Laboratory of Dioxins, Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain
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- Abad, Esteban (author)
- Laboratory of Dioxins, Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain
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- Dunstan, Jody (author)
- Waters Corporation, Manchester, United Kingdom
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- Jones, Rhys (author)
- Waters Corporation, Manchester, United Kingdom
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- Kotz, Alexander (author)
- EU Reference Laboratory (EURL) for Dioxins and PCBs in Feed and Food, State Institute for Chemical and Veterinary Analysis of Food, Freiburg, Germany
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- Winterhalter, Helmut (author)
- EU Reference Laboratory (EURL) for Dioxins and PCBs in Feed and Food, State Institute for Chemical and Veterinary Analysis of Food, Freiburg, Germany
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- Malisch, Rainer (author)
- EU Reference Laboratory (EURL) for Dioxins and PCBs in Feed and Food, State Institute for Chemical and Veterinary Analysis of Food, Freiburg, Germany
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- Traag, Wim (author)
- RIKILT, Institute of Food Safety, Wageningen, Netherlands
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- Hagberg, Jessika, 1974- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Ericson Jogsten, Ingrid, 1980- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Beltran, Joaquim (author)
- Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain
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- Hernandez, Felix (author)
- Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain
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(creator_code:org_t)
- 2015-08-21
- 2015
- English.
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In: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 87:17, s. 9047-9053
- Related links:
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http://repositori.uj...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The use of a new atmospheric-pressure chemical ionization source for gas chromatography (APGC) coupled with a tandem quadrupole mass spectrometry (MS/MS) system, as an alternative to high-resolution mass spectrometry (HRMS), for the determination of PCDDs/PCDFs is described. The potential of using atmospheric-pressure chemical ionization (APCI) coupled to a tandem quadrupole analyzer has been validated for the identification and quantification of dioxins and furans in different complex matrices. The main advantage of using the APCI source is the soft ionization at atmospheric pressure, which results in very limited fragmentation. APCI mass spectra are dominated by the molecular ion cluster, in contrast with the high energy ionization process under electron ionization (El). The use of the molecular ion as the precursor ion in MS/MS enhances selectivity and, consequently, sensitivity by increasing the signal-to-noise ratios (S/N). For standard solutions of 2,3,7,8-TCDD, injections of 10 fg in the splitless mode on 30- or 60-m-length, 0.25 mm inner diameter (id), and 25 mu m film thickness low-polarity capillary columns (DB5MS type), signal-to-noise (S/N) ratios of >10:1 were routinely obtained. Linearity was achieved in the region (correlation coefficient of r(2) > 0.998) for calibration curves ranging from 100 fg/mu L, to 1000 pg/mu L. The results from a wide variety of complex samples, including certified and standard reference materials and samples from several QA/QC studies, which were previously analyzed by EI HRGC/HRMS, were compared with the results from the APGC/MS/MS system. Results between instruments showed good agreement both in individual congeners and toxic equivalence factors (TEQs). The data show that the use of APGC in combination with MS/MS for the analysis of dioxins has the same potential, in terms of sensitivity and selectivity, as the traditional HEMS instrumentation used for this analysis. However, the APCI/MS/MS system, as a benchtop system, is much easier to use.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Keyword
- Analytical Chemistry
- Analytisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van Bavel, Bert, ...
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Geng, Dawei, 198 ...
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Cherta, Laura
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Nacher-Mestre, J ...
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Portoles, Tania
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Abalos, Manuela
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show more...
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Saulo, Jordi
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Abad, Esteban
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Dunstan, Jody
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Jones, Rhys
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Kotz, Alexander
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Winterhalter, He ...
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Malisch, Rainer
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Traag, Wim
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Hagberg, Jessika ...
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Ericson Jogsten, ...
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Beltran, Joaquim
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Hernandez, Felix
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Analytical Chemi ...
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Analytical Chemi ...
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Örebro University