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CD137 is expressed ...
CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice
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- Olofsson, Peder S. (author)
- Karolinska Institutet
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- Söderström, Leif A. (author)
- Karolinska Institutet
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- Wågsäter, Dick (author)
- Karolinska Institutet,Örebro universitet,Hälsoakademin,University of Örebro, Sweden
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- Sheikine, Yuri (author)
- Karolinska Institutet
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- Ocaya, Pauline (author)
- Örebro universitet,Institutionen för klinisk medicin,University of Örebro, Sweden
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- Lang, François (author)
- INSERM U601, Nantes, France
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- Rabu, Catherine (author)
- INSERM U601, Nantes, France
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- Chen, Lieping (author)
- Johns Hopkins University School of Medicine, Baltimore, USA
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- Rudling, Mats (author)
- Karolinska Institutet
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- Aukrust, Pål (author)
- University of Oslo, Norway
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- Hedin, Ulf (author)
- Karolinska Institutet
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- Paulsson-Berne, Gabrielle (author)
- Karolinska Institutet
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- Sirsjö, Allan (author)
- Örebro universitet,Hälsoakademin,University of Örebro, Sweden
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- Hansson, Göran K. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Baltimore, Md. Lippincott Williams & Wilkins, 2008
- 2008
- English.
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In: Circulation. - Baltimore, Md. : Lippincott Williams & Wilkins. - 0009-7322 .- 1524-4539. ; 117:10, s. 1292-1301
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Background— Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rupture and thrombosis. Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L have been implicated in atherosclerosis. Methods and Results— This study shows that the tumor necrosis factor superfamily members CD137 and CD137 ligand (CD137L), which play a major role in several autoimmune diseases, may constitute a pathogenic pair in atherogenesis. We detected CD137 protein in human atherosclerotic lesions not only on T cells but also on endothelial cells and showed that CD137 in cultured endothelial cells and smooth muscle cells was induced by proinflammatory cytokines implicated in atherosclerosis. Activation of CD137 by CD137L induced adhesion molecule expression on endothelial cells and reduced smooth muscle cell proliferation. In addition, treatment of atherosclerosis-prone apolipoprotein E–deficient mice with a CD137 agonist caused increased inflammation. T-cell infiltration, mainly of CD8+ cells, and expression of the murine major histocompatibility complex class II molecule I-Ab increased significantly in atherosclerotic lesions, as did the aortic expression of proinflammatory cytokines. Conclusions— Taken together, these observations suggest that CD137-CD137L interactions in the vasculature may contribute to the progression of atherosclerosis via augmented leukocyte recruitment, increased inflammation, and development of a more disease-prone phenotype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- 4-1BB Ligand/metabolism
- Animals
- Antigens; CD137/agonists/metabolism/*physiology
- Apolipoproteins E/deficiency/genetics
- Atherosclerosis/etiology/immunology/*metabolism
- Carotid Arteries/cytology/physiology
- Cells; Cultured
- Histocompatibility Antigens Class II/metabolism
- Humans
- Hypercholesterolemia/complications/metabolism
- Inflammation
- Mice
- Mice; Inbred C57BL
- Mice; Knockout
- RNA; Messenger/metabolism
- Renal Artery/cytology/physiology
- Statistics; Nonparametric
- MEDICINE
- MEDICIN
- Cardiovascular medicine
- Kardiovaskulär medicin
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Olofsson, Peder ...
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Söderström, Leif ...
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Wågsäter, Dick
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Sheikine, Yuri
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Ocaya, Pauline
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Lang, François
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show more...
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Rabu, Catherine
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Chen, Lieping
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Rudling, Mats
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Aukrust, Pål
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Hedin, Ulf
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Paulsson-Berne, ...
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Sirsjö, Allan
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Hansson, Göran K ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation
- By the university
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Örebro University
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Linköping University
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Karolinska Institutet