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- Olsman [Takner], HelenaÖrebro universitet,Institutionen för naturvetenskap,Bioanalytisk miljötoxikologi (author)
Relative differences in aryl hydrocarbon receptor-mediated response for 18 polybrominated and mixed halogenated dibenzo-p-dioxins and -furans in cell lines from four different species
- Article/chapterEnglish2007
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- 2007
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- LIBRIS-ID:oai:DiVA.org:oru-4714
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-4714URI
- https://doi.org/10.1897/07-004R.1DOI
Supplementary language notes
- Language:English
- Summary in:English
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- As a consequence of ubiquitous use of brominated organic chemicals, there is a concern for persistent or increasing environmental levels of polybrominated dibenzo-p-dioxins/furans (PBDD/Fs) and mixed polychlorinated and polybrominated dibenzo-p-dioxins/furans (PXDD/Fs). Hence, there is a need to broaden the toxicological and environmental knowledge about these compounds, as a basis for risk assessment. In the study presented here, the relative potencies (REPs) for 18 PBDD/F and PXDD/ F congeners were determined in four dioxin-specific bioassays from different species: dioxin receptor chemically activated luciferase expression assay (DR-CALUX, rat hepatoma cells), TV101L (human hepatoma cells), and GPC.2D (guinea pig adenoma cells), as well as ethoxyresorufin-O-deethylase induction in the fish cell line RTL-W1 (rainbow trout liver cells). The bioassay specific REP factors presented here enable the assessment of the contribution from PBDD/Fs and PXDD/Fs to total 2,3,7,8-tetrachl orodibenzop-dioxin (TCDD) equivalents (TEQs: toxic equivalents), using bioassay analysis. The PBDD/Fs were found to be equally potent as their chlorinated analogues in the three mammalian assays, whereas the PXDD/Fs showed relatively higher potencies. Of special concern were the 2,3,7,8-substituted penta- and tetrahalogenated congeners, for which mean REPs were >= 1. The 2-B-1,3,7,8-CDD (2-bromo-1,3,7,8-tetrachlorodibenzo-p-dioxin) was up to three times more potent than TCDD in individual experiments (on weight basis). The RTL-W1 was less sensitive to the tested compounds with overall 10-fold lower REPs than the mammalian cell lines. Although the REP factors exhibited species-specific differences, overall resembling rank orders of dioxin-like potency were obtained.
Subject headings and genre
- NATURVETENSKAP Kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences hsv//eng
- NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
- NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
- Adenoma/pathology
- Animals
- Biological Assay
- Cell Line
- Dioxins/*toxicity
- Environmental Pollutants/*toxicity
- Furans/*toxicity
- Guinea Pigs
- Humans
- Hydrocarbons; Brominated/toxicity
- Hydrocarbons; Halogenated/*toxicity
- Liver/*drug effects/pathology
- Oncorhynchus mykiss
- Rats
- Receptors; Aryl Hydrocarbon/*metabolism
- Risk Assessment
- Tetrachlorodibenzodioxin/toxicity
- NATURAL SCIENCES
- NATURVETENSKAP
- Chemistry
- Kemi
- Environmental chemistry
- Miljökemi
- Environmental toxicology
- Miljötoxikologi
- Miljökemi
- Environmental Chemistry
Added entries (persons, corporate bodies, meetings, titles ...)
- Engwall, MagnusÖrebro universitet,Institutionen för naturvetenskap,Bioanalytisk miljötoxikologi(Swepub:oru)mel (author)
- Kammann, Ulrike (author)
- Klempt, Martin (author)
- Otte, Jens (author)
- van Bavel, BertÖrebro universitet,Institutionen för naturvetenskap(Swepub:oru)bvl (author)
- Hollert, Henner (author)
- Örebro universitetInstitutionen för naturvetenskap (creator_code:org_t)
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- In:Environmental Toxicology and Chemistry26:11, s. 2448-24540730-72681552-8618
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