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Treatment of chroni...
Treatment of chronic hepatitis B infection : an update of Swedish recommendations
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- Lindh, Magnus, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Uhnoo, Ingrid (author)
- Swedish Medical Products Agency, Uppsala, Sweden
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- Bläckberg, Jonas (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Duberg, Ann-Sofi (author)
- Örebro universitet,Hälsoakademin
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- Friman, Styrbjörn, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Fischler, Björn (author)
- Karolinska Institutet
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Karlström, Olof (author)
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- Norkrans, Gunnar, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Reichard, Olle (author)
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- Sangfeldt, Per (author)
- Uppsala universitet,Infektionssjukdomar
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Söderström, Ann, 1961 (author)
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- Sönnerborg, Anders (author)
- Karolinska Institutet
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- Weiland, Ola (author)
- Karolinska Institutet
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- Wejstål, Rune, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Wiström, Johan, 1949- (author)
- Umeå universitet,Infektionssjukdomar
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(creator_code:org_t)
- 2009-07-08
- 2008
- English.
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In: Scandinavian Journal of Infectious Diseases. - London : Taylor & Francis. - 0036-5548 .- 1651-1980. ; 40:6-7, s. 436-450
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Abstract
Subject headings
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- The main goal for treatment of chronic hepatitis B is to prevent complications such as liver cirrhosis or hepatocellular carcinoma. Knowledge from population studies of the long-term risk of chronic HBV infection, as well as the recent introduction of pegylated interferon and additional nucleoside analogues has changed the therapeutic situation. Recently, a Swedish expert panel convened to update the national recommendations for treatment. The panel recommends treatment for patients with active HBV infection causing protracted liver inflammation or significant liver fibrosis, verified by liver histology. In general, pegylated interferon alpha-2a is recommended as first-line treatment, in particular for HBeAg-positive patients with HBV genotypes A or B. Among nucleoside analogues, entecavir is the first choice and adefovir or tenofovir can be used as alternatives. Lamivudine monotherapy is not recommended due to the high risk of resistance development. Combinations of nucleoside analogues such as tenofovir and lamivudine or emtricitabine are alternatives for patients with non-response or infection with resistant variants, or as first choice for patients with advanced liver disease. Nucleoside analogue treatment should be monitored to detect primary non-response and virological breakthrough. Special recommendations are given for HBV/HIV coinfected patients, immunosuppressed patients, children, and for treatment before and after liver transplantation. The present guideline is translated from Swedish, where it is published on the MPA and RAV websites (www.mpa.se and www.rav.nu.se) including 7 separate papers based on thorough literature search. The complete reference list can be received from the Medical Products Agency upon request.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Adenine/analogs & derivatives/therapeutic use
- Antiviral Agents/*therapeutic use
- Carcinoma; Hepatocellular/prevention & control
- Deoxycytidine/analogs & derivatives/therapeutic use
- Drug Therapy; Combination
- Guanine/analogs & derivatives/therapeutic use
- HIV Infections/complications
- Hepatitis B; Chronic/complications/*drug therapy
- Humans
- Immunocompromised Host
- Interferon Alfa-2a/therapeutic use
- Lamivudine/therapeutic use
- Liver Cirrhosis/prevention & control
- Liver Transplantation
- Phosphonic Acids/therapeutic use
- Polyethylene Glycols/therapeutic use
- Sweden
- MEDICINE
- MEDICIN
- Infectious diseases
- Infektionssjukdomar
- Infektionssjukdomar
- Infectious Diseases
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Lindh, Magnus, 1 ...
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Uhnoo, Ingrid
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Bläckberg, Jonas
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Duberg, Ann-Sofi
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Friman, Styrbjör ...
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Fischler, Björn
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Karlström, Olof
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Norkrans, Gunnar ...
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Reichard, Olle
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Sangfeldt, Per
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Söderström, Ann, ...
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Sönnerborg, Ande ...
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Weiland, Ola
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Wejstål, Rune, 1 ...
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Wiström, Johan, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Örebro University
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Umeå University
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Uppsala University
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Lund University
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Karolinska Institutet
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University of Gothenburg