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Renal cell carcinom...
Renal cell carcinoma recurrences and metastases in primary non-metastatic patients : a population-based study
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- Dabestani, Saeed (author)
- Department of Urology, Skåne University Hospital, Malmö, Sweden
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- Thorstenson, Andreas (author)
- Section of Urology, Department of Molecular Medicine and Surgery, Karolinska Institute Solna, Stockholm, Sweden
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- Lindblad, Per, 1953- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology, Örebro University Hospital, Örebro, Sweden
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- Harmenberg, Ulrika (author)
- Karolinska Institutet
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- Ljungberg, Börje (author)
- Umeå universitet,Urologi och andrologi
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- Lundstam, Sven (author)
- Department of Urology, Sahlgrenska University Hospital, Gothenburg, Sweden
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(creator_code:org_t)
- 2016-02-05
- 2016
- English.
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In: World journal of urology. - New York, USA : Springer. - 0724-4983 .- 1433-8726. ; 34:8, s. 1081-1086
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Purpose: To present the occurrence of metastases and local recurrences in primary non-metastatic patients with renal cell carcinoma (RCC) in a contemporary Swedish population-based cohort.Methods: Between 2005 and 2009, a total of 4527 patients were included in the prospective National Swedish Kidney Cancer Register accounting for nearly all RCC patients in Sweden. Among M0 patients, 472 (13 %) had no follow-up data registered within 5-year follow-up time and were excluded from the analysis.Results: In total, 939 (21 %) had distant metastases at presentation with a decrease from 23 to 18 % during the inclusion period. Of 3107 patients with follow-up data and with M0 disease, 623 (20 %) were diagnosed with a tumor recurrence during 5-year follow-up. Mean time to recurrence was 24 months (SD ± 20 months). Among these, 570 patients (92 %) were at primary diagnosis treated with radical nephrectomy, 23 patients (3.7 %) with partial nephrectomy and 12 patients (1.9 %) with minimally invasive treatments. The most frequent sites of metastases were lung (54 %), lymph nodes (22 %) and bone (20 %). The treatment of recurrence was in 50 % systemic treatments, while metastasectomy was performed in 17 % of the patients, out of which 68 % were with a curative intention.Conclusions: In this population-based study, 21 % of the patients had metastatic disease at presentation, with a decreasing trend over the study period. During 5-year follow-up, 20 % of the primary non-metastatic patients had recurrent disease. Of the patients with recurrence, half were given systemic oncological treatment and 17 % underwent metastasectomy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Renal cell carcinoma
- metastases
- recurrent disease
- local recurrence
- surgery
- nephrectomy
- partial nephrectomy
- minimal invasive therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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