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- Jayaprakash, Kartheyaene,1983-Örebro universitet,Institutionen för medicinska vetenskaper (author)
Monocyte and Neutrophil Inflammatory Responses to the Periodontopathogen Porphyromonas gingivalis
- BookEnglish2016
Publisher, publication year, extent ...
- Örebro :Örebro university,2016
- 63 s.
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-48228
- ISBN:9789175291222
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-48228URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Series
- Örebro Studies in Medicine,1652-4063 ;138
Notes
- Periodontitis is one of the most common adult infections. Duing bacteremia in healthy individuals or patients with chronic periodontitis, a number of oral bacteria such as Porphyromonas gingivalis encounter inflammatory cells in the blood eg. platelets, neutrophils and monocytes. Although several studies have suggested an association between periodontitis and cardiovascular diseases, the infection and inflammatory mechanisms are poorly understood. Hence, the aim of this thesis was to elucidate the mechanisms that are involved in P. gingivalis interaction with blood leukocytes, in order to further understand the molecular pathogenesis that renders periodontitis as a risk factor for several systemic conditions. We have demonstrated that P. gingivalis induces ROS production in neutrophils, THP1 cells and in whole blood, through activation of pattern recognition receptors, such as toll-like receptors, nuclear oligomerizing domains and protease- activated receptors. Besides, we have also shown that monocytes secrete IL-1β and CXCL8 in response to P. gingivalis. Both these cytokines prime neutrophils, endothelial cells and other vascular cells in an autocrine and paracrine manner. P. gingivalis has a plethora of virulence factors of which gingipains are very unique. In addition to activating inflammatory signalling pathways in cells, gingipains also regulate CXCL8 and IL-1β, thereby curtailing the host defence strategies. We demonstrated that oxidized LDL, but not native LDL, induces IL-1β release and CD36 expression on THP1 cells. Furthermore, LDL mildly modifies P. gingivalis-induced inflammatory responses as well as CD36 expression in THP1 cells. We also observed that P. gingivalis is eliminated mainly by phagocytosis in neutrophils. In summary, these studies clarify the mechanisms of interaction between P. gingivalis and leukocytes, which can increase the understanding of the pathogenesis of periodontitis and associated systemic disorders.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Andra medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Other Basic Medicine hsv//eng
- Monocytes
- Neutrophils
- Porphyromonas gingivalis
- Gingipains
- Biomedicin
- Biomedicine
Added entries (persons, corporate bodies, meetings, titles ...)
- Bengtsson, Torbjörn,ProfessorÖrebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)tbn (thesis advisor)
- Sirsjö, Allan,ProfessorÖrebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)aso (thesis advisor)
- Khalaf, HazemÖrebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)hkf (thesis advisor)
- Johansson, Anders,DocentInstitutionen för Odontologi, Umeå universitet (opponent)
- Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
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