The expression of EGFR family ligands in breast carcinomas

Suo, ZhenheDepartments of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, Norway (author)

Expression of EGF, HB-EGF, TGF-alpha, HRG-alpha, HRG-beta1, and HRG-beta3 in 100 frozen breast carcinoma materials was immunohistochemically studied. Among these tumors, 67% were positive for EGF, 53% for HB-EGF, 57% for TGF-alpha, 60% for HRG-alpha, 53% for HRG-beta1, and 63% for HRG-beta3 in the neoplastic epithelial cells. No significant associations between expression of the growth factors and clinicopathological features like tumor size, histologic grade, node status, ploidy, ER status, and c-erbB-4 expression were observed, with the exceptions that significant relations were present between EGF expression and tumor size (p = 0.01) and between HRG-beta3 expression and node status (p = 0.02). The expressions of these growth factors showed no association with cancer-specific survival by the Kaplan Meier analysis.

Risberg, BjørnDepartments of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, Norway (author)
Karlsson, Mats G,1960-Department of Pathology, Örebro Medical Center Hospital, Örebro, Sweden(Swepub:oru)mskn (author)
Villman, KennethDepartment of Oncology, Örebro Medical Center Hospital, Örebro, Sweden (author)
Skovlund, EvaDepartment of Clinical Research, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, Norway (author)
Nesland, Jahn M.Departments of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, Norway (author)
Departments of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, NorwayDepartment of Pathology, Örebro Medical Center Hospital, Örebro, Sweden (creator_code:org_t)

In:International Journal of Surgical PathologyThousand Oaks, USA : Sage Publications10:2, s. 91-991066-89691940-2465

By the author/editor: Suo, Zhenhe; Risberg, Bjørn; Karlsson, Mats G ...; Villman, Kenneth; Skovlund, Eva; Nesland, Jahn M.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

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