Increase in CD4+ and CD45RO+ memory T cells in the nasal mucosa of allergic patients

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Karlsson, Mats G.,1960-Departments of Pathology and Otorhionolaryngology, Medical Center Hospital, Örebro, Sweden (author)

Increase in CD4+ and CD45RO+ memory T cells in the nasal mucosa of allergic patients

Article/chapterEnglish1994

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Hoboken, USA :Wiley-Blackwell,1994
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LIBRIS-ID:oai:DiVA.org:oru-49529
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49529URI
https://doi.org/10.1111/j.1699-0463.1994.tb05230.xDOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

By means of immunocytochemistry we have investigated subsets of T lymphocytes in frozen sections of nasal mucosa from patients with seasonal allergic rhinitis and healthy control persons. All participants were subjected to time-course provocation during the non-pollen season, and samples were taken during provocation as well as during the natural pollen season. Computerized image analysis was applied for evaluation of the immunostained lymphocytes. CD45RO+ memory T cells outnumbered the remaining leukocyte populations in the mucosa of both allergic patients and controls on all occasions. During the repeat provocation there was no difference in numerical values, with respect to any of the five leukocyte subpopulations studied (CD4, CD8, CD25, CD45RA and CD45RO), between patients and controls. However, during continuous exposure in the pollen season a significant increase in CD4+ cells was observed in allergic patients compared to before provocation (p < 0.05). No changes were observed with respect to CD8+ and CD25+ cells. Similarly, an increase in CD45RO+ memory was found in allergic patients during the pollen season compared to the non-pollen season (p < 0.02). This latter finding was, however, only evident in the patients who did not use nasal corticosteroids. Hence the present investigation has demonstrated an allergen-induced increase in CD4+ and CD45RO+ memory T cells in the mucosa of allergic patients during the pollen season. These events may constitute a cellular basis for local continuous production of certain cytokines, particularly interleukin-4, which is essential for IgE synthesis.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Klinisk laboratoriemedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Clinical Laboratory Medicine hsv//eng
T lymphocytes
T helper cells
memory T cells
nasal allergy
immunocytochemistry

Added entries (persons, corporate bodies, meetings, titles ...)

Davidsson, Åke,1956-Departments of Pathology and Otorhionolaryngology, Medical Center Hospital, Örebro, Sweden(Swepub:oru)adn (author)
Hellquist, Henrik B.Department of Pathology II, University Hospital, Linköping, Sweden (author)
Departments of Pathology and Otorhionolaryngology, Medical Center Hospital, Örebro, SwedenDepartment of Pathology II, University Hospital, Linköping, Sweden (creator_code:org_t)

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In:Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)Hoboken, USA : Wiley-Blackwell102:10, s. 753-7580903-46411600-0463

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