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TMPRSS2:ERG gene fu...
TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort
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Demichelis, F. (author)
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- Fall, K. (author)
- Karolinska Institutet
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Perner, S. (author)
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- Andrén, Ove, 1963- (author)
- Örebro universitet,Hälsoakademin
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Schmidt, F. (author)
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Setlur, S.R. (author)
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Hoshida, Y. (author)
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Mosquera, J-M. (author)
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- Pawitan, Y. (author)
- Karolinska Institutet
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Lee, C. (author)
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- Adami, H-O. (author)
- Karolinska Institutet
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Mucci, L.A. (author)
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Kantoff, P.W. (author)
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Andersson, S-O. (author)
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Chinnaiyan, A.M. (author)
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- Johansson, Jan-Erik (author)
- Örebro universitet,Hälsoakademin
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Rubin, M.A. (author)
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(creator_code:org_t)
- 2007-01-22
- 2007
- English.
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In: Oncogene. - Basingstoke : Nature Publ. Group. - 0950-9232 .- 1476-5594. ; 26:31, s. 4596-4599
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https://www.nature.c...
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https://urn.kb.se/re...
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Abstract
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- The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, P<0.01, 95% confidence interval=1.3–5.8). Quantitative reverse-transcription–polymerase chain reaction demonstrated high estrogen-regulated gene (ERG) expression to be associated with TMPRSS2:ERG fusion (P<0.005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Surgery
- Kirurgi
- Oncology
- Onkologi
- Onkologi
- Oncology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Oncogene
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To the university's database
- By the author/editor
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Demichelis, F.
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Fall, K.
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Perner, S.
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Andrén, Ove, 196 ...
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Schmidt, F.
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Setlur, S.R.
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show more...
-
Hoshida, Y.
-
Mosquera, J-M.
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Pawitan, Y.
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Lee, C.
-
Adami, H-O.
-
Mucci, L.A.
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Kantoff, P.W.
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Andersson, S-O.
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Chinnaiyan, A.M.
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Johansson, Jan-E ...
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Rubin, M.A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Oncogene
- By the university
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Örebro University
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Karolinska Institutet