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Gas chromatography/...
Gas chromatography/atmospheric pressure chemical ionization/mass spectrometry for the analysis of organochlorine pesticides and polychlorinated biphenyls in human serum
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- Geng, Dawei, 1986- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre,Örebro universitet, Institutionen för naturvetenskap och teknik
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- Ericson Jogsten, Ingrid, 1980- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre,Örebro universitet, Institutionen för naturvetenskap och teknik
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- Dunstan, Jody (author)
- Waters Corporation, Manchester, United Kingdom
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- Hagberg, Jessika, 1974- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,MTM Research Centre,Örebro universitet, Institutionen för naturvetenskap och teknik
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- Wang, Thanh, 1979- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre,Örebro universitet, Institutionen för naturvetenskap och teknik
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- Ruzzin, Jerome (author)
- Department of Biology, University of Bergen, Bergen, Norway
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- Rabasa-Lhoret, Rémi (author)
- Institut de Recherches Cliniques de Montréal, Montréal QC, Canada; Montreal Diabetes Research Centre at the Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM) Montréal QC, Canada; Nutrition Department of Université de Montréal, Montréal QC, Canada; Endocrinology Division, Montreal University Hospital, Montréal QC, Canada
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Norwegian Institute for Water Research (NIVA), Oslo, Norway,MTM Research Centre,Örebro universitet, Institutionen för naturvetenskap och teknik
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(creator_code:org_t)
- Amsterdam, Netherlands : Elsevier, 2016
- 2016
- English.
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In: Journal of Chromatography A. - Amsterdam, Netherlands : Elsevier. - 0021-9673 .- 1873-3778. ; 1453, s. 88-98
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- A method using a novel atmospheric pressure chemical ionization source for coupling gas chromatography (GC/APCI) to triple quadrupole mass spectrometry (MS/MS) for the determination of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) regulated by the Stockholm Convention is presented. One microliter injection of a six-point calibration curve of native PCBs and OCPs, ranging from 0.04 to 300 pg/μL, was performed. The relative standard deviation (RSD) of the relative response factors (RRFs) was less than 15% with a coefficient of determination (r2) >0.995. Meanwhile, two calibration solutions (CS), CS 2 (0.4 pg/μL) and CS 3 (4 pg/μL) were analyzed to study the repeatability calculated for both area and RRFs. The RSD for RRF ranged from 3.1 to 16% and 3.6 to 5.5% for CS 2 and CS 3, respectively. The limits of detection (LOD) determined by peak-to-peak signal-to-noise ratio (S/N) of 3 were compared between the GC/APCI/MS/MS and a GC coupled to high resolution mass spectrometry (GC/HRMS) system. GC/APCI/MS/MS resulted in lower LOD for most of the compounds, except for PCB#74, cis-chlordane and trans-chlordane. GC/APCI/MS/MS and GC/HRMS were also compared by performing analysis on 75 human serum samples together with eight QA/QC serum samples. The comparison between GC/APCI/MS/MS system and GC/HRMS system for 16 of the targeted compounds was carried out. No statistically significant difference was discovered. Due to increased sensitivity and user friendly operation under atmospheric pressure, GC/APCI/MS/MS is a powerful alternative technique that can easily meet the specification of GC/HRMS.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- PCBs
- OCPs
- atmospheric pressure chemical ionization (APCI)
- triple quadrupole mass spectrometry (MS/MS)
- high resolution mass spectrometry (GC/HRMS)
- human serum
- Analytical Chemistry
- Analytisk kemi
- Environmental Chemistry
- Miljökemi
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Geng, Dawei, 198 ...
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Ericson Jogsten, ...
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Dunstan, Jody
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Hagberg, Jessika ...
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Wang, Thanh, 197 ...
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Ruzzin, Jerome
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Rabasa-Lhoret, R ...
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van Bavel, Bert, ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Journal of Chrom ...
- By the university
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Örebro University
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Linköping University