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Reduced inflammatio...
Reduced inflammation in relapsing-remitting multiple sclerosis after therapy switch to rituximab
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- de Flon, Pierre (author)
- Umeå universitet,Klinisk neurovetenskap
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- Gunnarsson, Martin, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurology
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- Laurell, Katarina (author)
- Umeå universitet,Klinisk neurovetenskap
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- Söderström, Lars (author)
- Unit of Research, Education and Development, Region Jämtland Härjedalen, Sweden
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- Birgander, Richard (author)
- Umeå universitet,Diagnostisk radiologi
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- Lindqvist, Thomas (author)
- Umeå universitet,Diagnostisk radiologi
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- Krauss, Wolfgang, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Radiology
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- Dring, Ann (author)
- Umeå universitet,Klinisk neurovetenskap
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- Bergman, Joakim (author)
- Umeå universitet,Klinisk neurovetenskap
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- Sundström, Peter (author)
- Umeå universitet,Klinisk neurovetenskap
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- Svenningsson, Anders (author)
- Karolinska Institutet,Umeå universitet,Klinisk neurovetenskap,Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- Philadelphia, USA : Lippincott Williams & Wilkins, 2016
- 2016
- English.
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In: Neurology. - Philadelphia, USA : Lippincott Williams & Wilkins. - 0028-3878 .- 1526-632X. ; 87:2, s. 141-147
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: To describe the effects of switching treatment from ongoing first-line injectable therapies to rituximab on inflammatory activity measured by MRI and levels of CSF neurofilament light chain (CSF-NFL) in a cohort of patients with clinically stable relapsing-remitting multiple sclerosis (RRMS).Method: Seventy-five patients with clinically stable RRMS treated with the first-line injectables interferon-β (IFN-β) and glatiramer acetate (GA) at 3 Swedish centers were switched to rituximab in this open-label phase II multicenter study. After a run-in period of 3 months, 2 IV doses of 1,000 mg rituximab were given 2 weeks apart followed by repeated clinical assessment, MRI, and CSF-NFL for 24 months.Results: The mean cumulated number of gadolinium-enhancing lesions per patient at months 3 and 6 after treatment shift to rituximab was reduced compared to the run-in period (0.028 vs 0.36, p = 0.029). During the first year after treatment shift, the mean number of new or enlarged T2 lesions per patient was reduced (0.01 vs 0.28, p = 0.004) and mean CSF-NFL levels were reduced by 21% (p = 0.01).Conclusions: For patients with RRMS, a treatment switch from IFN or GA to rituximab is associated with reduced inflammatory activity measured by MRI and CSF-NFL.Classification of evidence: This study provides Class IV evidence that rituximab has an equal or superior effect in reducing inflammatory activity in RRMS measured by MRI and CSF-NFL compared to first-line injectables during the first year after treatment shift.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Neurology
- Neurologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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- By the author/editor
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de Flon, Pierre
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Gunnarsson, Mart ...
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Laurell, Katarin ...
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Söderström, Lars
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Birgander, Richa ...
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Lindqvist, Thoma ...
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Krauss, Wolfgang ...
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Dring, Ann
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Bergman, Joakim
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Sundström, Peter
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Svenningsson, An ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Neurology
- By the university
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Örebro University
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Umeå University
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Karolinska Institutet